Results 51 to 60 of about 927 (131)

Table_1_TRIM3 attenuates cytokine storm caused by Dabie bandavirus via promoting Toll-like receptor 3 degradation.PDF

, 2023
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by the Dabie bandavirus (DBV), and it has become a global public health threat. Cytokine storm is considered to be an important pathogenesis of
Zhan Yang, Ke Jin (129426), Dafeng Lu, Chunhui Wang (141889), Jin Zhu (164147), Chunhui Wang, Huaying Huang (12425661), Ke Ouyang, Yan Dai (345965), Chunyan Wang, Ke Jin, Zhengyi Jiang, Jun Li, Nannan Hu, Xiaoguang Liu, Chunyan Wang (306606), Dafeng Lu (11660233), Jin Zhu, Jun Li (6494), Ke Ouyang (12425658), Hong Lin, Hong Lin (46089), Xuewei Sun, Huaying Huang, Zhengyi Jiang (6037655), Tingting Zhou, Xuewei Sun (14199572), Nannan Hu (8845373), Xiaoguang Liu (109982), Chuanlong Zhu (3966347), Chuanlong Zhu, Tingting Zhou (163678), Yan Dai, Zhan Yang (1627759)   +33 more
core   +1 more source

An Explainable Machine Learning Model for Early Prediction of Incident Myocardial Injury in Patients With Severe Fever With Thrombocytopenia Syndrome

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT This study aimed to develop an explainable machine learning–based model to enable early prediction of incident myocardial injury during hospitalization among patients with severe fever with thrombocytopenia syndrome (SFTS). This multicenter retrospective cohort study included and analyzed clinical data from 1,088 patients with SFTS who were ...
Xiang Li, Xiaotong Yu, Wei Zhou, Sujuan Zhang, Zibo Fan, Yuanni Liu, Yi Shen, Zhenghua Zhao, Jianping Duan, Ling Lin, Zhihai Chen, Wei Zhang   +11 more
wiley   +1 more source

Tick‐Tac‐Foe: When Ticks, Trade, and Zoonotic Pathogens Align in African Wet Meat Markets

Public Health Challenges, Volume 5, Issue 2, June 2026.
ABSTRACT Zoonotic diseases account for over ∼60% of infectious diseases and present a significantly growing fatality threat in Africa. Live and wet markets (LWMs) in Africa function as key economic venues that support human livelihoods through social interaction and trade in food stuff, including meat and other animal‐based products.
Allen Takudzwa Munaro
wiley   +1 more source

Data_Sheet_1_Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System.PDF

, 2021
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the tick-borne SFTS bunyavirus (SFTSV) resulting in a high fatality rate up to 30%.
Yun-Jia Ning (8605518), Hualin Wang (514306), Shu Shen (746509), Shiyu Dai (11276553), Min Zhou (173135), Fei Deng (170132), Fuli Ren (8685996), Junming Shi (11276556), Ding-Yu Zhang (9911148), Qiongya Wang (11276550), Chaolin Huang (9463406)   +10 more
core   +1 more source

Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model [PDF]

, 2022
Dabie bandavirus (previously severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus responsible for severe fever with thrombocytopenia syndrome (SFTS), a disease with high case fatality that is characterised by ...
Willett, Brian J, Brennan, Benjamin, Patel, Arvind H, Kohl, Alain, Patel, Arvind H., Gao, George F, Bryden, Steven R., Bryden, Steven R, Gao, George F., Dunlop, James I, Wu, Yan, Clarke, Andrew T, Dunlop, James I., Pingen, Marieke, Willett, Brian J., Clarke, Andrew T., Fares, Mazigh   +16 more
core   +1 more source

A humanized NOG‐EXL mouse model for producing severe fever with thrombocytopenia syndrome virus–reactive human antibodies

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 378-388, February 2026.
Humanized mouse models are essential for studying human immune response and antibody development. However, conventional models exhibit limited B cell maturation and antigen‐specific humoral responses. To overcome these limitations, we used the NOG‐EXL mice expressing human interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM ...
Dong Hoon Lee, Jiyeong Bae, Sumi Kim, Chan Young Song, Jung Hyu Shin, Eun Hee Kim, Chan Ho Jang, Young‐sun Yun, Dong‐sook Lee, Hyuk Chu, Jang‐Hoon Choi, Chan Woo Kim   +11 more
wiley   +1 more source

Insights on the phenology of the Asian longhorned tick (Haemaphysalis longicornis) using stored lipids

Insect Science, Volume 33, Issue 1, Page 396-406, February 2026.
Lipid analysis of field‐collected ticks unveiled a complex population structure and supports the potential for several stages to overwinter. Abstract The seasonality of Haemaphysalis longicornis in the United States comprises overlapping life stages in the spring and summer.
Matthew Bickerton, Julia González, Alvaro Toledo   +2 more
wiley   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Integration of SFTSV Viral Load, Age, and Double‐Negative B‐Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is a tick‐borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B‐cell dysregulation contributes to disease severity. Methods A cohort of 168 patients with confirmed SFTS was retrospectively analyzed. Flow cytometry was used
Wei Wei, Qian Tai, Heng Liu, Rujia Chen, Yun Wang, Ting Wang, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh   +10 more
wiley   +1 more source