Results 61 to 70 of about 1,016 (136)

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

A machine learning model for mortality prediction in patients with severe fever with thrombocytopenia syndrome: a prospective, multicenter cohort study

Emerging Microbes and Infections
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that imposes a considerable medical burden. In this study, we enrolled 1,606 SFTS patients, developed and validated machine learning models for mortality prediction, and
Yanan Liu, Lei Fan, Wencai Wang, Hongxuan Song, Zhenhua Zhang, Qian Liu, Zhongji Meng, Shibo Li, Hua Wang, Shijun Zhou, Wanjun Liu, Guomei Xia, Jianping Duan, Chunxia Guo, Lu Wang, Ling Xu, Tong Wang, Hanxin Li, Xinyue Zhang, Tiandan Xiang, Di Liu, Zujiang Yu, Yuliang Liu, Junzhong Wang, Xin Zheng   +24 more
doaj   +1 more source

Novel nomograms to predict risk and prognosis in hospitalized patients with severe fever with thrombocytopenia syndrome

Frontiers in Medicine, 2023
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging and life-threatening infectious disease caused by SFTS virus. Although recent studies have reported the use of nomograms based on demographic and laboratory data to predict the ...
Zhenxing Li, Zhaoru Zhang, Chong Chen
doaj   +1 more source

Pathogenesis and virulence of Heartland virus

Virulence
Heartland virus (HRTV), an emerging tick-borne pathogenic bunyavirus, has been a concern since 2012, with an increasing incidence, expanding geographical distribution, and high pathogenicity in the United States.
Kuan Feng, Benjamin Bendiwhobel Ushie, Haiyan Zhang, Shu Li, Fei Deng, Hualin Wang, Yun-Jia Ning   +6 more
doaj   +1 more source

Integration of SFTSV Viral Load, Age, and Double‐Negative B‐Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is a tick‐borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B‐cell dysregulation contributes to disease severity. Methods A cohort of 168 patients with confirmed SFTS was retrospectively analyzed. Flow cytometry was used
Wei Wei, Qian Tai, Heng Liu, Rujia Chen, Yun Wang, Ting Wang, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh   +10 more
wiley   +1 more source

T Follicular Helper Cell Immune Signatures Associated With Disease Severity in Severe Fever With Thrombocytopenia Syndrome

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is marked by high case fatality and profound antiviral immune dysregulation, yet the clinical implications of changes in circulating T follicular helper (Tfh) cells remain unclear. Methods We enrolled 79 patients with RT‐PCR‐confirmed SFTSV infection who were hospitalized from May to October
Danning Xu, Ting Wang, Wei Wei, Yun Wang, Rujia Chen, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh Prabu   +9 more
wiley   +1 more source

Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection

Frontiers in Microbiology, 2022
Severe fever with thrombocytopenia syndrome (SFTS), an emerging life-threatening infectious disease caused by SFTS bunyavirus (SFTSV; genus Bandavirus, family Phenuiviridae, order Bunyavirales), has been a significant medical problem.
Jiawen Sun, Jiawen Sun, Yuan-Qin Min, Yuan-Qin Min, Yunjie Li, Xiulian Sun, Xiulian Sun, Fei Deng, Fei Deng, Hualin Wang, Hualin Wang, Yun-Jia Ning, Yun-Jia Ning   +12 more
doaj   +1 more source

A One Health Assessment of Tick and Tick‐Borne Pathogen Diversity and Zoonotic Risk in Hubei Province, Central China

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Ticks and tick‐borne pathogens (TBPs) threaten livestock productivity and public health worldwide, and climate–land‐use change is expanding vector habitats, elevating tick‐borne disease risk. However, TBP diversity and risk in Hubei Province, central China, remain insufficiently defined within a One Health framework.
Qian Chen, Ning-wei Ma, Shi-ying Zhu, Dong-fang Li, Xiao-yan Lei, Zi-qian Zhou, Fen Du, Lan He, Jun-long Zhao, Ruofeng Yan   +9 more
wiley   +1 more source

Recent Advances in Humoral Immunity Dysregulation in Severe Fever With Thrombocytopenia Syndrome Virus (SFTSV) Infection: A Systematic Review

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Severe fever with thrombocytopenia syndrome virus (SFTSV) infection causes profound dysregulation of humoral immunity, leading to immunopathology and impaired viral clearance. However, the mechanisms underlying B cell dysfunction and inadequate antibody responses remain poorly defined.
Hongyan Hou, Xu Yuan, Rujia Chen, Zhigang Xiong, Shiji Wu, Feng Wang   +5 more
wiley   +1 more source