Results 61 to 70 of about 986 (161)

A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness. [PDF]

NPJ Vaccines
Several Bunyavirales families have been listed as being of high pandemic or epidemic risk by the WHO R&D Blueprint. To support pandemic preparedness and the 100 Days Mission, along with rapid provision of vaccines and therapeutics, the development of ...
Marchesin F, Bentley EM, Mutuku F, Jeza V, Ndenga B, Kempster S, Dowall SD, Almond N, Wright E, Banyard AC, Buczkowski H, Elaldi N, Mirazimi A, Hewson R, Rose NJ, Takeuchi Y, Mattiuzzo G.   +16 more
europepmc   +3 more sources

Heartland Virus Disease—An Underreported Emerging Infection

Microorganisms
First recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick (Amblyomma americanum) and potentially other tick species ...
Zygmunt F. Dembek, Jerry L. Mothershead, Christopher M. Cirimotich, Aiguo Wu   +3 more
doaj   +1 more source

NLR, A Convenient Early-Warning Biomarker of Fatal Outcome in Patients With Severe Fever With Thrombocytopenia Syndrome [PDF]

, 2022
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that greatly threatens public health. This study aimed to examine a convenient early-warning biomarker of fatal outcomes in patients with SFTS to reduce ...
Guizhou Zou, Honghai Xu, Jiabin Li, Jiabin Li, Jiangfeng Qin, Jiangfeng Qin, Lifen Hu, Lingling He, Lingling He, Luyang Kang, Nan Sheng, Nan Sheng, Shuangshuang Ma, Yuanyuan Wei, Yuanyuan Wei, Yufeng Gao, Yufeng Gao, Zilong Wang   +17 more
core   +1 more source

A humanized NOG‐EXL mouse model for producing severe fever with thrombocytopenia syndrome virus–reactive human antibodies

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 378-388, February 2026.
Humanized mouse models are essential for studying human immune response and antibody development. However, conventional models exhibit limited B cell maturation and antigen‐specific humoral responses. To overcome these limitations, we used the NOG‐EXL mice expressing human interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM ...
Dong Hoon Lee, Jiyeong Bae, Sumi Kim, Chan Young Song, Jung Hyu Shin, Eun Hee Kim, Chan Ho Jang, Young‐sun Yun, Dong‐sook Lee, Hyuk Chu, Jang‐Hoon Choi, Chan Woo Kim   +11 more
wiley   +1 more source

Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022 [PDF]

, 2023
BackgroundConducting an up-to-date analysis on the genomic diversity and evolution patterns of severe fever with thrombocytopenia syndrome virus (SFTSV) is crucial for elucidating the underlying mechanisms of its emergency and pathogenicity, as well as ...
Bo Pang, Hao Liang, Hongling Wen, Wei Ma, Xiaowen Chong, Xiaoying Xu, Xueying Tian, Yao Wang, Yao Wang, Zengqiang Kou, Zequn Wang   +10 more
core   +1 more source

Viral suppression of type I interferon signaling by NSs of DBV, SFSV and UUKV via NSs-mediated RIG-I degradation

Biosafety and Health, 2022
Phenuiviridae, a member of the Bunyavirales order, can lead to significant human morbidity and mortality. Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon (IFN).
Leling Xu, Xueping Li, Xiaoning Gao, Sihua Liu, Zheng Pang, Zhiyun Wang   +5 more
doaj   +1 more source

Insights on the phenology of the Asian longhorned tick (Haemaphysalis longicornis) using stored lipids

Insect Science, Volume 33, Issue 1, Page 396-406, February 2026.
Lipid analysis of field‐collected ticks unveiled a complex population structure and supports the potential for several stages to overwinter. Abstract The seasonality of Haemaphysalis longicornis in the United States comprises overlapping life stages in the spring and summer.
Matthew Bickerton, Julia González, Alvaro Toledo   +2 more
wiley   +1 more source

Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Small-Animal Veterinarians and Nurses in the Japanese Prefecture with the Highest Case Load

Viruses, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is the causative agent of SFTS, an emerging tick-borne disease in East Asia, and is maintained in enzootic cycles involving ticks and a range of wild animal hosts.
Yumi Kirino, Keita Ishijima, Miho Miura, Taro Nomachi, Eugene Mazimpaka, Putu Eka Sudaryatma, Atsushi Yamanaka, Ken Maeda, Takayuki Sugimoto, Akatsuki Saito, Hirohisa Mekata, Tamaki Okabayashi   +11 more
doaj   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Knowledge mapping of severe fever with thrombocytopenia syndrome: a bibliometric analysis [PDF]

BackgroundSevere fever with thrombocytopenia syndrome (SFTS), caused by the Dabie bandavirus (DBV), formerly known as the SFTS virus (SFTSV), is characterized by rapid progression, high morbidity, and mortality.
Huiying Zhang, Huiying Zhang, Leiliang Zhang, Leiliang Zhang   +3 more
core   +1 more source