Results 251 to 260 of about 1,181,577 (352)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Status and Trends of the Digital Healthcare Industry. [PDF]

Healthc Inform Res
Lee NK, Kim JS.
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Macrolevel Analysis of Labour Productivity Losses Associated With Breast Cancer Among Women in 47 African Countries. [PDF]

Glob Health Epidemiol Genom
Immurana M, Abdullahi I, Norshie K, Kale ER, Iddrisu AA, Tsey IH, Acquah E, Dalaba MA.   +7 more
europepmc   +1 more source

JWST detection of heavy neutron capture elements in a compact object merger

, 2023
Levan A, Gompertz B, Salafia OS, Bulla M, Burns E, Hotokezaka K, Izzo L, Lamb G, Malesani D, Oates S, Ravasio M, Escorial AR, Schneider B, Sarin N, Schulze S, Tanvir N, Ackley K, Anderson G, Brammer G, Christensen L, Dhillon V, Evans P, Fausnaugh M, Fong W, Fruchter A, Fryer C, Fynbo J, Gaspari N, Heintz K, Hjorth J, Kennea J, Kennedy M, Laskar T, Leloudas G, Mandel I, Martín-Carrillo A, Metzger B, Nicholl M, Nugent A, Palmerio J, Pugilese G, Rastinejad J, Rhodes L, Rossi A, Smartt S, Stevance H, Tohuvavohu A, Horst Avd, Vergani S, Watson D, Barclay T, Bhirombhakdi K, Breedt E, Breeveld A, Brown A, Campana S, D'Avanzo P, D'Elia V, De Pasquale M, Dyer M, Galloway D, Garbutt J, Green M, Hartmann D, Jakobsson P, Kerry P, Langeroodi D, Leung J, Littlefair S, Munday J, O'Brien P, Parsons S, Pelisoli I, Sahman D, Salvaterra R, Tagliaferri G, Thöne C, Postigo AdU, Sbarufatti B, Chrimes A, Steeghs D, Kann D.   +81 more
europepmc   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao, Xinhua Feng, Aifu Lin, Lei Zhao, Stephanie Roessler, Junfang Ji   +14 more
wiley   +1 more source

Bank Mergers : the synergy of mergers

, 2005
openaire   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Advanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang, Chenle Dong, Lefeng Su, Zhiqiang Liu, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang, Jiandong Yuan   +11 more
wiley   +1 more source

Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS

Advanced Science, EarlyView.
A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang, Jia‐Tong Yan, Mao‐Lin Li, Cui Zhou, Jian Wang, Shuo‐Bin Chen, Zhi‐Shu Huang, Jia‐Heng Tan   +7 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source