Results 41 to 50 of about 198,043 (299)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

FEATURES OF FUNCTIONING NATIONAL MODEL OF RESOURCE ECONOMICS IN UKRAINE

Фінансово-кредитна діяльність: проблеми теорії та практики, 2018
Introduction. Almost thirty years in the modern history of Ukraine were marked by modest economic and social outcomes. Extremely low rates of economic growth, price and exchange rate instability, technological backwardness of the majority of domestic ...
Serhii Kolodii, Inna Kochuma, Anatoly Marenych, Mykola Rudenko   +3 more
doaj   +1 more source

Information Retrieval Based on Brazilian Portuguese Texts [PDF]

Journal of Systemics, Cybernetics and Informatics, 2022
Knowledge-based intelligent systems might be used in the banking sector to automate customer service. One of the ways to represent knowledge that is both understandable by humans and readable by machines is by using ontologies.
Victor Hayashi, Mateus Carvalho, João Carlos Néto, Felipe Pinna, Rosangela Marquesone, Wilson Ruggiero, Maisa Duarte   +6 more
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Agent liquidity: A catalyst for mobile money banking among the unbanked poor population in rural sub-Saharan Africa [PDF]

, 2023
George Okello Candiya Bongomin, Charles Akol Malinga, Alain Amani Manzi, Rebecca Balinda   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bankacılık Sektöründe Çözümleme Maliyetinin Hesaplanması

Pamukkale Üniversitesi İşletme Araştırmaları Dergisi, 2021
Finansal Sektörde yaşanan krizler neticesinde küresel ölçekli birçok banka iflas noktasına gelmiştir. Bunlardan bazıları devletler eliyle kurtarılmış ancak bu kurtarma süreci ekonomiye ve dolayısıyla vergi ödeyenlere önemli ölçüde yük getirmiştir.
Ferhun Ateş, Güven Sayılgan
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source