Results 61 to 70 of about 1,247,076 (295)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
No Bank, One Bank, Several Banks: Does it Matter for Investment? [PDF]
SSRN Electronic Journal, 2010 This paper examines whether financial constraints affect firms’ investment decisions for older (larger) firms. We compare a group of unbanked firms to firms that rely on formal financing. Specifically, we combine data from the Spanish Mercantile Registry and the Bank of Spain Credit Registry (CIR) to classify firms according to their number of banking ...
Sonia Ruano +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
FINTECH – THE NEXT CHAPTER OF BANKING [PDF]
ეკონომიკური პროფილიThe swift development of financial technology, or fintech, has completely changed the financial services industry and created a new financial order where fintech is now a direct rival of traditional banks rather than a supplementary service.
Mirza Khidasheli
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The impact of climate change response disclosure on commercial bank performance in Vietnam
Discover SustainabilityIn the context of climate change increasingly exerting severe impacts on global socio-economic systems, Vietnam has set ambitious sustainable development goals, in which the banking sector plays a pivotal role in channeling green capital flows and ...
Hang Thu Do +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Information Retrieval Based on Brazilian Portuguese Texts [PDF]
Journal of Systemics, Cybernetics and Informatics, 2022 Knowledge-based intelligent systems might be used in the banking sector to automate customer service. One of the ways to represent knowledge that is both understandable by humans and readable by machines is by using ontologies.
Victor Hayashi +6 more
doaj
Banking reform in Vietnam [PDF]
Vietnam’s banking sector is expected to have one of the highest growth rates in Asia during the next few years due to the country’s continued economic expansion, rising household incomes, and relatively low penetration of existing banking services.
Anne Ho, R. Ashle Baxter
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source