Results 51 to 60 of about 5,556 (217)

Sustainable tourism and green space: exploring how green spaces and natural attractions contribute to local tourism economies and revenue generation in Gauteng province

Discover Sustainability
Green spaces and natural attractions are critical assets in promoting sustainable tourism, particularly in ecologically diverse regions such as South Africa.
Enioluwa Jonathan Ijatuyi, Kowiyou Yessoufou, Hosea Olayiwola Patrick   +2 more
doaj   +1 more source

Optimization of Natural Deep Eutectic Solvent-Assisted Extraction of Rosmarinic Acid from Thunbergia laurifolia Lindl. and Evaluation of Antioxidant Activity

Molecules
Thunbergia laurifolia Lindl. is a plant known for its promising biological activity, including antioxidant and anti-inflammatory activities, and a rich source of rosmarinic acid (RA). The extraction of T.
Krittima Kriengsaksri, Wisuwat Thongphichai, Tamonwan Uttarawichien, Jasadakorn Khoochonthara, Pasarapa Towiwat, Suchada Sukrong   +5 more
doaj   +1 more source

Sequencing of BAC pools by different next generation sequencing platforms and strategies

BMC Research Notes, 2011
Background Next generation sequencing of BACs is a viable option for deciphering the sequence of even large and highly repetitive genomes. In order to optimize this strategy, we examined the influence of read length on the quality of Roche/454 sequence ...
Scholz Uwe, Petzold Andreas, Felder Marius, Groth Marco, Schmutzer Thomas, Schulte Daniela, Ariyadasa Ruvini, Steuernagel Burkhard, Taudien Stefan, Mayer Klaus FX, Stein Nils, Platzer Matthias   +11 more
doaj   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Thoridae (Crustacea: Decapoda) can penetrate the Abyss: a new species of Lebbeus from the Sea of Okhotsk, representing the deepest record of the family

European Journal of Taxonomy, 2020
Lebbeus sokhobio sp. nov. is described from abyssal depths (3303−3366 m) in the Kuril Basin of the Sea of Okhotsk. The related congeners are deep-water dwellers with a very distant distribution and very similar morphology. The new species is separated by
Ivan Marin
doaj   +1 more source

DNA barcoding and eDNA barcoding in diatoms

, 2014
Die lichtmikroskopische Bewertung der Diversität von Diatomeen ist eine erfolgreich praktizierte Methode zur Gewässergüteanalyse, die z.B. auch in der Wasserrahmenrichtlinie der Europäischen Union umgesetzt wird. Die vorliegende Arbeit stellt environmental DNA (eDNA) Barcoding als Alternative zur üblichen Untersuchung von Diatomeengesellschaften mit ...
Zimmermann, Jonas, Justus Liebig University Giessen   +1 more
openaire   +2 more sources

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Three new species of Kynotus from the Central Highlands of Madagascar (Clitellata, Megadrili)

European Journal of Taxonomy, 2017
The earthworm fauna of Madagascar is scarcely known. A recently launched exploration of the soil fauna (“Global Change and Soil Macrofauna Diversity in Madagascar”) resulted in the discovery of six new earthworm species belonging to the Malagasy endemic ...
Csaba Csuzdi, Malalatiana Razafindrakoto, Yong Hong   +2 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source