Results 41 to 50 of about 225,878 (298)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A three-dimensional hydrodynamical line profile analysis of iron lines and barium isotopes in HD140283 [PDF]
, 2015 Heavy-elements, i.e. those beyond the iron peak, mostly form via two neutron capture processes: the s- and r-process. Metal-poor stars should contain fewer isotopes that form via the s-process, according to currently accepted theory. It has been shown in
Aoki, W. +3 more
core +4 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Adsorption of barium on surface of GaN(0001)
Физико-химические аспекты изучения кластеров, наноструктур и наноматериаловFor the first time, the adsorption of barium atoms on the surface of the (0001) face of GaN was calculated using the density functional method. The 2D GaN layer was modeled using a GaN(0001) 2×2 supercell containing 10 GaN bilayers.
M.N. Lapushkin
doaj +1 more source
Barium sulfate aspiration pneumonia: A fatal case of death
Clinical Case Reports, 2022 Accidental aspiration of barium is a rare event. We present the case of a patient who, after the administration of barium, he showed sudden cough with dyspnea and vomiting and chemical pneumonia with areas of consolidation.
Matteo Antonio Sacco +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Growth Rate, Ration, and Temperature Effects on Otolith Elemental Incorporation
Frontiers in Marine Science, 2020 The application and utility of otolith chemistry continues to expand despite an incomplete understanding of the mechanisms that regulate elemental incorporation.
Jessica A. Miller, Thomas P. Hurst
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source