Results 71 to 80 of about 106 (103)

Combined prediction of transmembrane topology and signal peptide of β-barrel proteins: Using a hidden Markov model and genetic algorithms

Computers in Biology and Medicine, 2010
Hidden Markov models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. The design of the model architecture and the algorithms for parameter estimation and decoding are extremely important for improve the performance of HMM.
Lingyun Zou, Zhengzhi Wang, Yongxian Wang, Fuquan Hu   +3 more
openaire   +2 more sources

TMBHMM: A frequency profile based HMM for predicting the topology of transmembrane beta barrel proteins and the exposure status of transmembrane residues

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
Transmembrane beta barrel (TMB) proteins are found in the outer membranes of bacteria, mitochondria and chloroplasts. TMBs are involved in a variety of functions such as mediating flux of metabolites and active transport of siderophores, enzymes and structural proteins, and in the translocation across or insertion into membranes. We present here TMBHMM,
Nitesh Kumar, Singh, Aaron, Goodman, Peter, Walter, Volkhard, Helms, Sikander, Hayat   +4 more
openaire   +2 more sources

Monoclonal antibodies against regions topologically surrounding the homodimeric β-barrel interface of Epstein-Barr virus nuclear antigen-1

Virus Research, 2005
Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA-1) is essential for maintenance of EBV latency. Four mouse monoclonal antibodies (mAbs) against the part of the EBNA-1 sequence (amino acids 451-641) containing the domain that forms a homodimeric eight-stranded beta-barrel were generated and characterized, examined for immunocytochemical staining ...
Hiroyuki, Eda, Yasuyuki, Ishii, Maya, Obayashi, Shizuko, Harada, Sayuri, Ito, Tomomichi, Fujita, Masato, Ikeda, Shuichi, Kusano, Ryo, Kitamura, Chieko, Suzuki, Takahiko, Hara, Motoo, Watanabe, Hiroshi, Satoh, Keisuke, Sugihara, Kazuo, Yanagi   +14 more
openaire   +2 more sources

Circular permutants in β-glucosidases (family 3) within a predicted double-domain topology that includes a (β/α)8-barrel

Proteins: Structure, Function, and Genetics, 1998
By predicting the general secondary structure for beta-glucosidases (family 3), in conjunction with existing knowledge of the circular permutants present in B. fibrisolvens and R. albus, we were able to find the canonical elements of the secondary structure. The way these elements are linked suggests that there is a double-domain topology made up of a (
S, García-Vallvé, A, Rojas, J, Palau, A, Romeu   +3 more
openaire   +2 more sources

Stability of barrelled topologies

1983
In the theory of locally convex topological vector spaces, barrelled topologies have been found to be stable under the formation of products, sums and quotients. We shall in this thesis investigate the stability of barrelled topologies with respect to two further mathematical constructions. Firstly, we examine the situation with regard to the formation
openaire   +1 more source

Sequence based methods for the prediction and analysis of the structural topology of transmembrane beta barrel proteins

2011
Die Klasse der Transmembranproteine übernimmt eine Reihe wesentlicher Funktionen innerhalb der Zelle. Daher eignen sich viele dieser Proteine als Ziele für medizinische Wirkstoffe und sind daher von außerordentlichem Interesse für die Pharmaindustrie.
openaire   +1 more source

A double-barrelled aorta with high aortic Arch

Journal of Cardiology Cases, 2021
Tsugutoshi Suzuki, Yuki Kawasaki, Takeshi Sasaki   +2 more
exaly  

Characterization of the folding and unfolding reactions of a small beta-barrel protein of novel topology, the MTCP1 oncogene product P13.

Journal of molecular biology, 2001
The equilibrium and kinetic folding properties of a small oncogene product, P13(MTCP1), of novel topology have been investigated using perturbation by guanidine hydrochloride and observation by fluorescence, circular dichroism and two-dimensional heteronuclear NMR spectroscopy. The structure of P13(MTCP1) is comprised of a canonical filled beta-barrel,
C, Roumestand, M, Boyer, L, Guignard, P, Barthe, C A, Royer   +4 more
openaire   +1 more source

Optimal design of spaceborne antenna supporting structure with loadbearing barrel-brackets configuration by topology optimization method

International Conference on Mechanical Design and Simulation (MDS 2022), 2022
Jungang Yang, Bingshan Liu, Yongbin Huang, Qiao Zhang, Tong Gao, Yong Xiao, Hao Duan, Zeliang Yu   +7 more
openaire   +1 more source

A pressure vessel with a special barrelled shape

Ocean Engineering, 2022
Krzysztof Magnucki, Paweł Jasion
exaly