Results 81 to 90 of about 1,202,492 (293)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

ACCESSIBILITY OF INCLUSIVE HIGHER EDUCATION THROUGH THE EYES OF STUDENTS WITH DISABILITIES

open access: yesAstra Salvensis, 2019
Currently, the problem of providing optimal conditions for the creative development, self-education and professional development of persons with disabilities is increasingly relevant for higher educational institutions of the Republic of Kazakhstan.
Guldana Ispambetova   +5 more
doaj  

Gender perspective on urban planning amidst European integration and post-conflict impact: The Ukrainian case

open access: yesEuropean Journal of Spatial Development
In post-conflict societies, urban development efforts typically prioritise reconstruction and accessibility. This paper examines the potential for integrating gender-responsive approaches into urban planning in Ukraine, where the priorities of post-war ...
Alirza Mamedov   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Statistical mechanics and thermodynamics of viral evolution

open access: yes, 2015
This paper analyzes a simplified model of viral infection and evolution using the 'grand canonical ensemble' and formalisms from statistical mechanics and thermodynamics to enumerate all possible viruses and to derive thermodynamic variables for the ...
Bianco, Simone   +3 more
core   +4 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Sign language recognition method based on deep learning [PDF]

open access: yesITM Web of Conferences
Sign language recognition, as an interdisciplinary field involving computer vision, pattern recognition, and natural language processing, holds profound research significance and extensive application value.
He Mu
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The use of GIS to study accessibility of the urban environment (case study of Secondary Cities project)

open access: yesProblemi Bezperervnoï Geografìčnoï Osvìti ì Kartografìï, 2018
Issues of social protection of people with disabilities, the state of introduction of such people into society as well as the accessibility of the environment are considered by many researchers.
Nataliia Popovych   +2 more
doaj  

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