Results 131 to 140 of about 1,951,061 (295)

Chapter 08: Vulnerability of seagrasses in the Great Barrier Reef to climate change [PDF]

, 2007
Seagrasses are flowering plants and, along with mangroves, have greater affinities to terrestrial plants than other marine macrophytes such as algae.
Udy, J., Grech, A., Waycott, M., McMahon, K., Collier, C., Ralph, P., McKenzie, L.J.   +6 more
core  

Weeds and problem animals on islands in the Great Barrier Reef World Heritage Area [PDF]

, 2001
Fisher, J., Turner, M., Anderson, O.
core   +1 more source

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

The Journal of Headache and Pain
Background Triptans are potent 5-HT1B/1D/1F receptor agonists used in migraine therapy, thought to act through peripheral mechanisms. It remains unclear whether triptans cross the blood-brain barrier (BBB) sufficiently to stimulate central 5-HT1B/1D/1F ...
Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hematological consequences of environmental change during dewilding of rhesus macaques

Nature Communications
The environment shapes immune system development and the regulation of inflammatory responses, however the hematological consequences of a major environmental change, such as those experienced during migration, remain poorly understood.
Annabelle Smith, Kasalina Kiwanuka, Gabriela Pessenda, Andrew R. Rahmberg, Jacob K. Flynn, Richard Herbert, Jason M. Brenchley, P’ng Loke   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Chapter 14: Vulnerability of seabirds on the Great Barrier Reef to climate change [PDF]

, 2007
Seabirds are highly visible, charismatic predators in marine ecosystems that are defined as feeding exclusively at sea, in either nearshore, offshore or pelagic waters.
Erwin, C.A., O'Neill, P., Baker, G.B., Congdon, B.C., Peck, D.R., Double, M.C.   +5 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source