Results 111 to 120 of about 3,535,669 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Field-driven solid-on-solid interfaces moving under a stochastic Arrhenius dynamic: effects of the barrier height

, 2005
We present analytical results and kinetic Monte Carlo simulations for the mobility and microscopic structure of solid-on-solid (SOS) interfaces driven far from equilibrium by an external force, such as an applied field or (electro)chemical potential ...
Ala-Nissila, Ala-Nissila, Bortz, Buendía, Burton, Erdélyi, G.M. Buendía, Katletz, Korniss, Korniss, M. Kolesik, Marro, Mitchell, Neergaard, P.A. Rikvold, Park, Pierre-Louis, Rikvold, Rikvold, Rikvold, Rikvold, Schmickler   +21 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Paradoxes sur le public.

EspacesTemps.net, 2007
L’État contemporain ne se rapporte pas aux citoyens de manière individualisée et concrète, il les convoque plutôt comme une masse formelle et dépersonnalisée. Par une instrumentalisation de la culture et des arts, il en fait des consommateurs d’œuvres et
Thibaut Barrier
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Understanding fluctuating climate change risk perceptions through the lens of trust: a study of Great Barrier Reef region residents

npj Climate Action
Public perceptions of climate change risks are fundamental to public support for climate action. From a decade of surveying residents in the Great Barrier Reef region (2013–2023; n = 9920), we found that climate risk perceptions have fluctuated markedly,
Elizabeth V. Hobman, Matthew I. Curnock, Michelle Dyer, Cindy Huchery, Petina L. Pert, Emilee Chamberland, Aditi Mankad   +6 more
doaj   +1 more source

Breaking the Barrier

, 2018
Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition ...
Giulbudagian, Michael, Yealland, Guy (Dr.), Hönzke, Stefan (Dr.), Edlich, Alexander (Dr.), Geisendörfer, Birte, Kleuser, Burkhard (Prof. Dr. rer. nat.), Hedtrich, Sarah, Calderón, Marcelo   +7 more
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Fluids and Barriers of the CNS
Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo Kp,uu,brain estimates are the gold standard for investigating brain drug disposition, animal usage is a limitation to
Kristine Langthaler, Christopher R. Jones, Lasse Saaby, Christoffer Bundgaard, Birger Brodin   +4 more
doaj   +1 more source