Results 91 to 100 of about 1,951,061 (295)
Chapter 18: Vulnerability of pelagic systems of the Great Barrier Reef to climate change [PDF]
, 2007 This review focuses on pelagic environments. The oceanography of the Great Barrier Reef (GBR) is dynamic and is the physical template to which organisms respond. Planktonic assemblages are the basis of pelagic food chains and they provide a rich supply
Welch, D.J., Kingsford, M.J.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Chapter 02: Climate and climate change on the Great Barrier Reef [PDF]
, 2007 The expectation of climate change due to the enhanced greenhouse effect is not new. Since Svante Arrhenius in the late 19th century suggested that changing greenhouse gas concentrations in the atmosphere could alter global temperatures and Callendar ...
Lough, J.M.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
EspacesTemps.net, 2007 L’État contemporain ne se rapporte pas aux citoyens de manière individualisée et concrète, il les convoque plutôt comme une masse formelle et dépersonnalisée. Par une instrumentalisation de la culture et des arts, il en fait des consommateurs d’œuvres et
Thibaut Barrier
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
npj Climate ActionPublic perceptions of climate change risks are fundamental to public support for climate action. From a decade of surveying residents in the Great Barrier Reef region (2013–2023; n = 9920), we found that climate risk perceptions have fluctuated markedly,
Elizabeth V. Hobman +6 more
doaj +1 more source
, 2018 Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition ...
Giulbudagian, Michael +7 more
openaire +2 more sources