Results 71 to 80 of about 1,704,518 (313)

Reef Beat education series: the amazing Great Barrier Reef, let's keep it great

open access: yes, 2013
The Great Barrier Reef Marine Park Authority’s 2013 Reef Beat education series, the amazing Great Barrier Reef — let’s keep it great, includes a poster (best viewed and printed in A0 size) and curriculum-linked activity book.

core   +1 more source

Exemple, explication et processus de démonstration

open access: yesAnnales de Didactique et de Sciences Cognitives, 2019
The article looks at the proving process in mathematics from a didactic perspective. The study seeks to identify what metamathematics knowledge is at stake when mathematicians produce proof of implications with universal quantifiers.
Thomas Barrier, Azzedine Hajji
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Permeable Reactive Barrier [PDF]

open access: yes, 2014
Remediation of groundwater is complex and often challenging. But the cost of pump and treat technology, coupled with the dismal results achieved, has paved the way for newer, better technologies to be developed.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Chapter 13: Vulnerability of chondrichthyan fishes of the Great Barrier Reef to climate change

open access: yes, 2007
This chapter addresses the potential impact of climate change on the chondrichthyan fauna of the Great Barrier Reef, that is, the sharks, rays, skates and holocephalans that occur within the Great Barrier Reef region.
Kyne, P.M., Chin, A.
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Vulnerability of macroalgae of the Great Barrier Reef to climate change

open access: yes, 2007
Assessing the vulnerability of benthic macroalgae is complicated by the fact that the taxon ‘algae’ is an unnatural (and, some suggest, outdated) grouping that encompasses several distinct and diverse evolutionary lines. Adl et al.3 suggest that ‘algae’
Smith, J.E.   +13 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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