Results 41 to 50 of about 45,518 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A density-barrier construction algorithm with minimum total movement in mobile WSNs

open access: yes, 2015
The barrier coverage problem is one of the most important issues in wireless sensor networks (WSNs). In previous research, scholars did not consider the actual density of sensors in the area.
Cheng, Chien-Fu; Wu, Ting-Ying; Liao, Hsien-Chun   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Research and Practice on the Influence of Hydropower Station Construction on River Connectivity in the Process of Urbanization

open access: yesRenmin Zhujiang, 2022
River connectivity features longitudinal,lateral,and vertical dimensions,as well as time.Specifically,the longitudinal dimension (longitudinal connectivity) is highly disturbed and widely affected by human activities in the process of urbanization.Based ...
WANG Shenfang   +2 more
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An exploratory study of information technology evaluation and benefits management practices of SMEs in the construction industry

open access: yes, 2004
While the number of articles on IT evaluation and benefits management has been substantial, limited attention has been given to these topics in small and medium-sized enterprises (SMEs), particularly the construction industry.
Irani, Z, Love, PED
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

The management of disputes as an element of construction transaction costs: an empirical study. [PDF]

open access: yes, 2020
The process of delivering construction projects is characterised by a multiplicity of transactions between individual organisations whose integration is vital yet problematic. The premise of this paper is that the management and resolution of contractual
Greenwood, David   +2 more
core  

Integrating sustainability into construction project management: Barriers in developing countries

open access: yesModern Building Materials, Structures and Techniques (MBMST), 2019
This paper is an attempt to explore the barriers to integrating sustainability into construction project management in developing countries. To this end, a comprehensive review of the literature is conducted, as a result of which a list of 30 barriers is culled from existing studies.
Ali Fathalizadeh   +4 more
openaire   +1 more source

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