Results 61 to 70 of about 506,686 (344)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Frontiers in Veterinary Science, 2021 An owner's ability to detect changes in the behavior of a dog afflicted with osteoarthritis (OA) may be a barrier to presentation, clinical diagnosis and initiation of treatment.
Claire Roberts +9 more
semanticscholar +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Barriers to women in the UK construction industry [PDF]
, 2010 Purpose – This paper aims to identify the main barriers that lead to the under-representation of women in the UK construction industry. The study, funded by ConstructionSkills, seeks to explore the issues that women face and investigate the potential ...
Harris, K +4 more
core +2 more sources
International Journal of Quality & Reliability Management, 2023 PurposeThe construction industry continues to struggle to deliver a right first time culture, seeking a panacea for improvement whilst maintaining project milestones.
Gavin Ford, J. Gosling, M. Naim
semanticscholar +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Identification of key process areas in the production on an e-capability maturity model for UK construction organisations [PDF]
, 2010 Uptake of e-procurement by construction organisations has been slow (Martin, 2008). Positive e-business achievements in other industries, point towards the potential for the construction industry to accomplish similar results.
Eadie, Robert +2 more
core +1 more source
Prioritization methodology for roadside and guardrail improvement: Quantitative calculation of safety level and optimization of resources allocation [PDF]
, 2018 The attention to road safety-related issues has grown fast in recent decades. The experience gained with these themes reveals the importance of considering these aspects in the resource allocation process for roadside and guardrail improvement, which is ...
Cantisani, Giuseppe +3 more
core +1 more source
Application of Epistemic Uncertainty Analysis and Sensitivity Analysis in Green Construction Design
Advances in Environmental and Engineering Research, 2022 Building performance is often expressed according to primary energy use; however studies should also include environmental load. To mitigate the effects of increased CO2 emissions, green building designs are now increasingly popular options for ...
Siera Sylvester +2 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source