Results 71 to 80 of about 1,829,399 (343)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Storm surge barrier performance—The effect of barrier failures on extreme water level frequencies

open access: yesJournal of Flood Risk Management
Sea level rise necessitates the upgrade of coastal flood protection including storm surge barriers. These large movable hydraulic structures are open in normal conditions, but close during a storm surge to prevent coastal floods in bays and estuaries ...
L. F. Mooyaart   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Creation and detection of a mesoscopic gas in a non-local quantum superposition

open access: yes, 2008
We investigate the scattering of a quantum matter wave soliton on a barrier in a one dimensional geometry and we show that it can lead to mesoscopic Schr\"odinger cat states, where the atomic gas is in a coherent superposition of being in the half-space ...
C. Cohen-Tannoudji   +4 more
core   +1 more source

Inverse barrier methods for linear programming [PDF]

open access: yesRAIRO - Operations Research, 1994
Summary: In the recent interior point methods for linear programming much attention has been given to the logarithmic barrier method. In this paper, we analyze the class of inverse barrier methods for linear programming, in which the barrier is \(\sum x^{- r}_i\), where \(r> 0\) is the rank of the barrier.
den Hertog, D., Roos, C., Terlaky, T.
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Stable Barrier-projection and Barrier-Newton methods in nonlinear programming [PDF]

open access: yesOptimization Methods and Software, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Evtushenko, Yuri G., Zhadan, Vitali G.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Correcting Inconsistency in Linear Inequalities by Minimal Change in the Right Hand Side Vector [PDF]

open access: yesComputer Science Journal of Moldova, 2009
Correcting an inconsistent set of linear inequalities by minimal changes in problem data is a well studied problem and up to now several algorithms have been developed to do this task. In this paper, we consider doing the minimal correction using the l 2
Saeed Ketabchi , Maziar Salahi
doaj  

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