Results 121 to 130 of about 1,327,323 (292)

Advances in biological barrier membranes for guided bone regeneration: Fabrication, characteristics, multifunctional optimization, and clinical prospects

Materials Today Sustainability
Alveolar bone defects with insufficient bone mass, caused by trauma, tumors, congenital disorders, and periodontal inflammation, severely hinder natural tooth preservation and dental implantation, a key challenge in modern oral medicine.
Hongwei Pan, Yue Qu, Xueqin Hui, Haiquan Yue   +3 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Nanoreagents Against the Blood-Testis Barrier: A Strategy for Diagnosing and Treating Male Reproductive System Diseases

International Journal of Nanomedicine
Guohui Zhang,1– 3,* Yuhong Zhao,1– 3,* Xinrong Du,4,* Ningjing Li,4 Min Jiang,4 Weiwei Zhi,5 Qin Zeng,5 Heqiu Yan,6 Jun Liu,4 Jiuzhi Zeng,5 Yangbao Miao,7 Weixin Liu1– 3 1Center of Women’s and Children’s Health Medical Research ...
Zhang G, Zhao Y, Du X, Li N, Jiang M, Zhi W, Zeng Q, Yan H, Liu J, Zeng J, Miao Y, Liu W   +11 more
doaj  

Control Barrier Function-Based Collision Avoidance Guidance Strategy for Multi-Fixed-Wing UAV Pursuit-Evasion Environment

Drones
In order to address the potential collision issue arising from multiple fixed-wing unmanned aerial vehicles (UAVs) intercepting targets in n-on-n and n-on-1 pursuit-evasion scenarios, we propose a collision-avoidance guidance strategy for UAVs based on ...
Xinyuan Lv, Chi Peng, Jianjun Ma
doaj   +1 more source

Extracellular Vesicles from Caveolin-Enriched Microdomains Regulate Hyaluronan-Mediated Sustained Vascular Integrity

International Journal of Cell Biology, 2015
Defects in vascular integrity are an initiating factor in several disease processes. We have previously reported that high molecular weight hyaluronan (HMW-HA), a major glycosaminoglycan in the body, promotes rapid signal transduction in human pulmonary ...
Tamara Mirzapoiazova, Frances E. Lennon, Bolot Mambetsariev, Michael Allen, Jacob Riehm, Valeriy A. Poroyko, Patrick A. Singleton   +6 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Multi-hollow dielectric barrier discharge plasma: An energy-efficient strategy towards mild ammonia synthesis

Fuel Processing Technology
Renewable-driven non-thermal plasma (NTP) technology provides a potentially sustainable alternative for ammonia (NH3) production. Nonetheless, energy efficiency remains a critical bottleneck in NTP reactors.
Shanzhi Liu, Jiabao Lv, Zhikai Lang, Xingqi Li, Jianhua Yan, Xiaodong Li, Yaqi Peng, Yunchao Li, Dingkun Yuan, Jian Wu, Angjian Wu   +10 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Stabilizing the integrity of intestinal barrier to control arthritis

Arthritis Research & Therapy
With great interest, we have read the recent article “Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery” published by Lyu et al. in Annals of the Rheumatic Diseases. The authors
George D. Kalliolias, Athanasios G. Papavassiliou   +1 more
doaj   +1 more source