Results 1 to 10 of about 3,935,589 (363)

Establishment of an in vitro model of cultured viable human, porcine and canine skin and comparison of different media supplements [PDF]

PeerJ, 2019
Transdermal drug delivery provides several advantages over conventional drug administration, such as the avoidance of first-pass metabolism and better patient compliance.
Isa Bauhammer, Manuel Sacha, Eleonore Haltner   +2 more
doaj   +2 more sources

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

Journal of Neuroinflammation, 2023
Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present.
Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke   +10 more
doaj   +1 more source

Delivery of RNA to the Blood-Brain Barrier Endothelium Using Cationic Bicelles

Pharmaceutics, 2023
Blood-brain barrier (BBB) dysfunction is prevalent in Alzheimer’s disease and other neurological disorders. Restoring normal BBB function through RNA therapy is a potential avenue for addressing cerebrovascular changes in these disorders that may lead to
Joan Cheng, Lushan Wang, Vineetha Guttha, Greg Haugstad, Karunya K. Kandimalla   +4 more
doaj   +1 more source

COMPARISONS OF THE HISTOLOGICAL MORPHOLOGY AND IN VITRO PERCUTANEOUS ABSORPTION OF CAFFEINE IN SHED SNAKE SKIN AND HUMAN SKIN

Slovenian Veterinary Research, 2020
The employment of excised skin (human or animal) mounted in diffusion cells is frequently used for the characterization of biopharmaceutical properties of topical semisolids dosage forms.
Manuel Sacha, Nancy Weisbach, Anna-Sophie Pöhler, Nina Demmerle, Eleonore Haltner   +4 more
doaj   +1 more source

A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation

Scientific Reports, 2022
Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology of HE is limited due to a paucity of well-characterized HE models beyond ...
Wouter Claeys, Lien Van Hoecke, Anja Geerts, Hans Van Vlierberghe, Sander Lefere, Griet Van Imschoot, Elien Van Wonterghem, Bart Ghesquière, Roosmarijn E. Vandenbroucke, Christophe Van Steenkiste   +9 more
doaj   +1 more source

Blood–brain barrier disruption in atrial fibrillation: a potential contributor to the increased risk of dementia and worsening of stroke outcomes?

Open Biology, 2021
Atrial fibrillation (AF) has become one of the most significant health problems worldwide, warranting urgent answers to currently pending questions on the effects of AF on brain function.
Ritambhara Aryal, Adjanie Patabendige
doaj   +1 more source

Mapping the dynamics of insulin-responsive pathways in the blood–brain barrier endothelium using time-series transcriptomics data

npj Systems Biology and Applications, 2022
Critical functions of the blood–brain barrier (BBB), including cerebral blood flow, energy metabolism, and immunomodulation, are regulated by insulin signaling pathways.
Zengtao Wang, Xiaojia Tang, Suresh K. Swaminathan, Karunya K. Kandimalla, Krishna R. Kalari   +4 more
doaj   +1 more source

Inuit youth and environmental research: exploring engagement barriers, strategies, and impacts

FACETS, 2022
Community leadership in Arctic environmental research is increasingly recognized as one of many pathways to Indigenous self-determination in Nunavut, Canada.
Hilary Sadowsky, Nicolas D. Brunet, Alex Anaviapik, Abraham Kublu, Cara Killiktee, Dominique A. Henri   +5 more
doaj   +1 more source

Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation

Frontiers in Immunology, 2023
Microglia, the resident macrophages of the central nervous system (CNS), play a critical role in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating factor 1 (CSF1) receptor inhibitor, is widely used to deplete microglia ...
Wouter Claeys, Wouter Claeys, Wouter Claeys, Wouter Claeys, Daan Verhaege, Daan Verhaege, Griet Van Imschoot, Griet Van Imschoot, Elien Van Wonterghem, Elien Van Wonterghem, Lore Van Acker, Lore Van Acker, Laura Amelinck, Laura Amelinck, Federico F. De Ponti, Federico F. De Ponti, Charlotte Scott, Charlotte Scott, Anja Geerts, Anja Geerts, Anja Geerts, Christophe Van Steenkiste, Christophe Van Steenkiste, Lien Van Hoecke, Lien Van Hoecke, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke   +26 more
doaj   +1 more source

Helping Our Students Reach Their Full Potential: The Insidious Consequences of Stereotype Threat [PDF]

, 2016
A psychological phenomenon may be a significant cause of academic underachievement by minorities in law school. This phenomenon, called stereotype threat, occurs as a result of the fear of confirming a negative group stereotype (such as African-Americans
McClain, Russell A
core   +2 more sources