Results 1 to 10 of about 274 (71)

Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons [PDF]

eLife, 2020
Micturition requires precise control of bladder and urethral sphincter via parasympathetic, sympathetic and somatic motoneurons. This involves a spino-bulbospinal control circuit incorporating Barrington’s nucleus in the pons (Barr).
Hiroki Ito, Anna C Sales, Christopher H Fry, Anthony J Kanai, Marcus J Drake, Anthony E Pickering   +5 more
doaj   +2 more sources

Barrington’s Nucleus: A Pontine Defecation Brain Area Exhibiting Prompt and Delayed Defecation ResponsesSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Chronic constipation has attracted considerable attention because of its negative impact on quality of life. Although defecation depends on local anorectal motility coordinated by the central nervous system, how it is regulated by ...
Kota Bussaka, Yoshimasa Tanaka, Kunio Kondoh, Ken-ichiro Nakajima, Takatoshi Chinen, Xiaopeng Bai, Yosuke Minoda, Hiroko Ikeda, Kazuki Inamura, Tsubasa Takeshima, Haruei Ogino, Eikichi Ihara, Yasuhiko Minokoshi, Yoshihiro Ogawa   +13 more
doaj   +2 more sources

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract. [PDF]

J Comp Neurol
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Gasparini S, Zhu H, Munuzuri ASP, Leuang ML, Fazan FS, Geerling JC.   +5 more
europepmc   +2 more sources

Whole-Brain Neural Connectivity to Cholinergic Neurons in the Lower Thoracic Intermediolateral Column. [PDF]

CNS Neurosci Ther
This study establishes a whole‐brain monosynaptic input map to cholinergic neurons in the lower thoracic intermediolateral column (IML) using a cell‐type‐specific retrograde rabies tracing system in ChAT‐Cre mice. Our results reveal a widespread supraspinal network originating from five major brain divisions, including the telencephalon, diencephalon ...
Yang YJ, Zhang KY, Li BB, Liu XW, Li JR, Liu YN, Liu YH, Li J, Yuan XS, Zhong M.   +9 more
europepmc   +2 more sources

AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice. [PDF]

J Comp Neurol
Retro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Zhu H, Geerling JC.
europepmc   +2 more sources

Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats. [PDF]

Eur J Neurosci
Coordinated postnatal emergence of CRH‐ergic innervation (red) and perineuronal nets (green) in spinal micturition centers (blue) defines a sexually dimorphic timeline of circuit stabilization, highlighting a critical period for hormonally regulated visceromotor maturation (see manuscript). ABSTRACT Pelvic visceromotor functions such as micturition are
Nitabara A, Banjo Y, Takiguchi M, Funakoshi K.   +3 more
europepmc   +2 more sources

Effects of Vornorexant, a Dual Orexin Receptor Antagonist, on Bladder Function in Rats and Nocturnal Voiding Frequency in Patients With Insomnia. [PDF]

Int J Urol
ABSTRACT Objectives Nocturia has been reported to exacerbate sleep disturbances, such as insomnia and poor sleep quality, resulting in increased risks of falls, fractures, and mortality. These consequences significantly impact the physical health and overall prognosis of patients.
Hikichi H, Chino Y, Takahashi T, Kawaura K, Kambe D, Hino N.   +5 more
europepmc   +2 more sources

Splanchnic and Pelvic Spinal Afferent Pathways Relay Sensory Information From the Mouse Colorectum Into Distinct Brainstem Circuits. [PDF]

J Neurochem
This study used transneuronal viral tracer to identify the spinal cord and brainstem circuits connected to the colorectum in the mouse (A). To establish if the regions of the brainstem labelled from the colon were functionally relevant to colorectal sensory‐motor processing, the distribution of neurons activated by distending the colon was mapped (B ...
Wang Q, McGovern AE, Kyloh M, Rychkov G, Spencer NJ, Mazzone SB, Brierley SM, Harrington AM.   +7 more
europepmc   +2 more sources

Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat. [PDF]

J Comp Neurol
In this article, we provide an extensive neuroanatomical characterization of a recently generated CRFR1‐Cre‐2A‐tdTomato rat. We show that Cre and tdTomato are expressed in a pattern that closely aligns with previously reported CRFR1 expression patterns.
Engelke DS, Ugartemendia L, Tao J, Rajamanikam S, Do Monte FH, Justice NJ.   +5 more
europepmc   +2 more sources

The Locus Coeruleus-Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review. [PDF]

Eur J Neurol
The locus coeruleus (LC) is a small brainstem nucleus that serves as the main source of noradrenaline for the central nervous system, influencing a wide range of cognitive and physiological processes. By integrating anatomical, neurochemical, and functional perspectives, this review provides a comprehensive understanding of the LC‐NA system's role in ...
Caestecker S, Lescrauwaet E, Boon P, Carrette E, Raedt R, Vonck K.   +5 more
europepmc   +2 more sources