Molecular Detection of Bartonella spp. in China and St. Kitts
Bartonella are vector‐borne hemotropic bacteria that infect a wide variety of hosts, including people. While there are PCR assays that can identify individual or groups of Bartonella, there is no reliable molecular method to simultaneously detect all species while maintaining genus specificity and sensitivity.
Ke Huang +7 more
wiley +1 more source
In silico analysis of Pap31 from Bartonella bacilliformis and other Bartonella spp.
Pap31 is an outer membrane protein of Bartonella bacilliformis which is considered to be a potential antigenic candidate for the development of diagnostic tools. The present study aimed to compare Pap31 from B. bacilliformis with that of other Bartonella
Gomes, Claudia, Ruiz, Joaquim
core +1 more source
Dried blood spots for qPCR diagnosis of acute Bartonella bacilliformis infection. [PDF]
Bartonella bacilliformis is the etiological agent of a life-threatening illness. Thin blood smear is the most common diagnostic method for acute infection in endemic areas of Peru but remains of limited value because of low sensitivity.
Smit PW +6 more
europepmc +2 more sources
Semantic Modeling for Exposomics with Exploratory Evaluation in Clinical Context
Exposome is a critical dimension in the precision medicine paradigm. Effective representation of exposomics knowledge is instrumental to melding nongenetic factors into data analytics for clinical research. There is still limited work in (1) modeling exposome entities and relations with proper integration to mainstream ontologies and (2) systematically
Jung-wei Fan +3 more
wiley +1 more source
Highly Sensitive Loop‐Mediated Isothermal Amplification for the Detection of Leptospira
Leptospirosis is a worldwide zoonosis caused by an infection with the pathogenic species of Leptospira. We have developed a loop‐mediated isothermal amplification (LAMP) assay to detect the DNA of Leptospira spp. Six sets of primers targeting the gene of the subsurface protein, lipL32, were evaluated for their detection sensitivity. The best primer set
Hua-Wei Chen +6 more
wiley +1 more source
Interplay of the Gastric Pathogen Helicobacter pylori with Toll‐Like Receptors
Toll‐like receptors (TLRs) are crucial for pathogen recognition and downstream signaling to induce effective immunity. The gastric pathogen Helicobacter pylori is a paradigm of persistent bacterial infections and chronic inflammation in humans. The chronicity of inflammation during H.
Suneesh Kumar Pachathundikandi +5 more
wiley +1 more source
Adhesion and host cell modulation: critical pathogenicity determinants of Bartonella henselae [PDF]
Bartonella henselae, the agent of cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis, contains to date two groups of described pathogenicity factors: adhesins and type IV secretion systems.
Kempf Volkhard AJ +5 more
core +1 more source
A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors [PDF]
Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These effectors may interfere with each other to efficiently control the infection process.
Okujava, Rusudan +36 more
core +2 more sources
Cutaneous leishmaniasis (CL) is endemic in Khyber Pakhtunkhwa (KP) Province of Pakistan, and exploring its epidemiological status is critical for its control. The current study described the spatial occurrence of CL and its associated risk factors in KP.
Khurshaid Khan +5 more
wiley +1 more source
An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp
Pathogen recognition receptors (PRRs) are a class of germ line‐encoded receptors that recognize pathogen‐associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first‐line defense until more specific adaptive immunity is developed.
Ji-Hyun Jang +6 more
wiley +1 more source

