Results 151 to 160 of about 32,167,916 (377)

Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

, 2017
Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a subjective visual
Adabi, Saba, Clayton, Anne, Conforto, Silvia, Daveluy, Steven, Hosseinzadeh, Matin, Mehregan, Darius, Nasiriavanaki, Mohammadreza, Noei, Shahryar   +7 more
core   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Nascent flagellar basal bodies are immobilized by rod assembly in Bacillus subtilis

mBio
Flagella are complex, trans-envelope nanomachines that localize in species-specific patterns on the cell surface. Here, we study the localization dynamics of the earliest stage of basal body formation in Bacillus subtilis using a fluorescent fusion to ...
Caroline M. Dunn, Daniel J. Foust, Yongqiang Gao, Julie S. Biteen, Sidney L. Shaw, Daniel B. Kearns   +5 more
doaj   +1 more source

Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis

Biology Open, 2012
Summary Defects in cilia and basal bodies function are linked to ciliopathies, which result in kidney cyst formation. Recently, cell division defects have been observed in cystic kidneys, but the underlying mechanisms of such defects remain unclear. Wtip
Ekaterina Bubenshchikova, Koichiro Ichimura, Yayoi Fukuyo, Rebecca Powell, Chaonan Hsu, Stephen O. Morrical, John R. Sedor, Tatsuo Sakai, Tomoko Obara   +8 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

Journal of Cell Biology, 2011
Eight proteins, defects in which are associated with Meckel-Gruber syndrome and nephronophthisis ciliopathies, work together as two functional modules at the transition zone to establish basal body/transition zone connections with the membrane and ...
Corey L. Williams, Chunmei Li, K. Kida, P. N. Inglis, Swetha Mohan, Lucie Semenec, Nathan J. Bialas, Rachel M. Stupay, Nansheng Chen, O. Blacque, B. Yoder, M. Leroux   +11 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling

Journal of Cell Biology, 2012
In contrast to vertebrate CBY, which functions in WNT signaling, Drosophila CBY is essential for normal basal body structure and function but dispensable for Wg signaling.
Camille Enjolras, Joëlle Thomas, Brigitte Chhin, Elisabeth Cortier, Jean-Luc Duteyrat, F. Soulavie, Maurice J. Kernan, A. Laurençon, B. Durand   +8 more
semanticscholar   +1 more source

BASAL CARDIAC FUNCTION AND BODY COMPOSITION WITH SPECIAL REFERENCE TO OBESITY 1 [PDF]

, 1952
Henry L. Taylor, Josef Brožek, Ancel Keys, Walter M. Carlson   +3 more
openalex   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source