Results 121 to 130 of about 27,260,641 (372)
Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model
Neurobiology of Disease, 2016 Dissociation of vasomotor and metabolic responses to levodopa has been observed in human subjects with Parkinson's disease (PD) studied with PET and in autoradiograms from 6-hydroxydopamine (6-OHDA) rat. In both species, acute levodopa administration was
Renata P. Lerner +6 more
doaj
Electrophysiological signatures of anxiety in Parkinson’s disease
Translational PsychiatryAnxiety is a common non-motor symptom in Parkinson’s disease (PD) occurring in up to 31% of the patients and affecting their quality of life. Despite the high prevalence, anxiety symptoms in PD are often underdiagnosed and, therefore, undertreated.
Sahar Yassine +6 more
doaj +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Posttraumatic Bilateral Basal Ganglia Bleed: A Report of Three Extremely Rare Cases
Indian Journal of Neurosurgery, 2019 Basal ganglia bleed, though common in hypertensive, is unusual in posttraumatic patients. Bilateral basal ganglia hematoma following trauma is extremely rare and is limited to few case reports.
Musali Siddartha Reddy +3 more
doaj +1 more source
Advanced Science, EarlyView.Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen +12 more
wiley +1 more source
White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study
NeuroImage: Clinical, 2019 Mood depressive disorder is one of the most disabling chronic diseases with a high rate of everyday life disability that affects 350 million people around the world.
Julie Coloigner +6 more
doaj
Pediatric Research, 2017 BackgroundThis study aims to (i) compare volumes of individual basal ganglia nuclei (caudate nucleus, pallidum, and putamen) and the thalamus between very preterm (VP) and term-born infants at term-equivalent age; (ii) explore neonatal basal ganglia and ...
Wai Yen Loh +10 more
semanticscholar +1 more source
Dopa-responsive dystonia and hyperprolactinaemia : a novel association in two sisters [PDF]
, 2007 Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a "hereditary progressive basal ganglia disease with marked diurnal ...
Cachia, Mario J., Galea, Janabel
core
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source