Results 181 to 190 of about 27,260,641 (372)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang   +9 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund   +4 more
wiley   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

open access: yesAdvanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang   +16 more
wiley   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

open access: yesAdvanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong   +11 more
wiley   +1 more source

Movement disorders in astrocytomas of the basal ganglia and the thalamus. [PDF]

open access: bronze, 1992
Joachim K. Krauss   +5 more
openalex   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

open access: yesAdvanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu   +9 more
wiley   +1 more source

Bioinspired Intelligent Soft Robotics: From Multidisciplinary Integration to Next‐Generation Intelligence

open access: yesAdvanced Science, EarlyView.
Soft robotics, featuring intrinsic compliance and biomimetic adaptability, emerges as transformative in next‐generation intelligent systems. This review outlines how advancements in four foundational domains—actuation, materials, manufacturing, and control—drive the evolution of bioinspired intelligent soft robotics, poised to redefine the boundaries ...
Xiaopeng Wang   +7 more
wiley   +1 more source

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