Results 21 to 30 of about 132,485 (264)

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

open access: yesNeurobiology of Disease, 2011
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo   +5 more
doaj   +1 more source

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

open access: yesNeurobiology of Disease, 2009
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane   +2 more
doaj   +1 more source

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

open access: yesNeurobiology of Disease, 2008
The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD).
E.L. Lane   +4 more
doaj   +1 more source

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat

open access: yesNeurobiology of Disease, 2006
Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia.
E.L. Lane   +3 more
doaj   +1 more source

Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report

open access: yeseNeurologicalSci, 2021
Autoimmune basal ganglia encephalitis causes neurological symptoms such as parkinsonism associated with basal ganglia lesions. Here, we report a case of autoimmune basal ganglia encephalitis without retinal lesions or malignancy harboring anti-recoverin ...
Yuki Kitazaki   +8 more
doaj   +1 more source

Receptors in the Basal Ganglia [PDF]

open access: yesCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1987
ABSTRACT:The study of neurotransmitter receptors aids in the understanding of the normal anatomy, pharmacology, therapeutics and pathophysiology of disease processes involving the basal ganglia. Receptors may be studied in vitro by homogenate binding experiments, enzyme analysis or quantitative autoradiography and in vivo with positron emission ...
openaire   +2 more sources

Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model

open access: yesNeurobiology of Disease, 2016
Dissociation of vasomotor and metabolic responses to levodopa has been observed in human subjects with Parkinson's disease (PD) studied with PET and in autoradiograms from 6-hydroxydopamine (6-OHDA) rat. In both species, acute levodopa administration was
Renata P. Lerner   +6 more
doaj   +1 more source

Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children

open access: yesBrain Sciences, 2020
Diseases primarily affecting the basal ganglia in children result in characteristic disturbances of movement and muscle tone. Both experimental and clinical evidence indicates that the basal ganglia also play a role in higher mental states.
Justyna Paprocka   +3 more
doaj   +1 more source

PDZD8 is not the ‘functional ortholog’ of Mmm1, it is a paralog [version 1; referees: 2 approved]

open access: yesF1000Research, 2018
Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells.
Jeremy G. Wideman   +3 more
doaj   +1 more source

The correlation between lateralization of intracerebral hemorrhage in basal ganglia and handedness [PDF]

open access: yesActa Cirúrgica Brasileira, 2013
PURPOSE: To investigate the correlation between lateralization of cerebral basal ganglia hemorrhage and handedness. METHODS: Medical records and computed tomography (CT) scans for 84 patients with primary hypertensive intracerebral hemorrhage (ICH) in ...
Yu Cui   +6 more
doaj   +3 more sources

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