Results 21 to 30 of about 157,060 (309)

Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease

Neurobiology of Disease, 2017
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow ...
Irene Sebastianutto, Maria Angela Cenci, Tim Fieblinger   +2 more
doaj   +1 more source

How ‘Basal' Are the Basal Ganglia? [PDF]

Brain, Behavior and Evolution, 2013
years ago [Erwin et al., 2011], did not merely have a substantial rostral brain, but specifically a telencephalon, an elaborate set of forebrain structures hitherto recognized only in vertebrates. The set of structures that Strausfeld and Hirth [2013a] identify as the arthropod homolog of the basal ganglia is the central complex, a group of median ...
openaire   +2 more sources

Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion

Neurobiology of Disease, 2016
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD).
Francesco Bez, Veronica Francardo, M. Angela Cenci   +2 more
doaj   +1 more source

Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Neurobiology of Disease, 2016
Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of ...
Irene Sebastianutto, Natallia Maslava, Corey R. Hopkins, M. Angela Cenci   +3 more
doaj   +1 more source

Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia

Neurobiology of Disease, 2004
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi, Jenny E. Westin, Manolo Carta, Molly E. Eaton, Katarzyna Kuter, Andrzej Dekundy, Martin Lundblad, M. Angela Cenci   +7 more
doaj   +1 more source

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

Neurobiology of Disease, 2011
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo, Alessandra Recchia, Nataljia Popovic, Daniel Andersson, Hans Nissbrandt, M. Angela Cenci   +5 more
doaj   +1 more source

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

Neurobiology of Disease, 2009
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane, Patrik Brundin, M. Angela Cenci   +2 more
doaj   +1 more source

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

Neurobiology of Disease, 2008
The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD).
E.L. Lane, D. Soulet, L. Vercammen, M.A. Cenci, P. Brundin   +4 more
doaj   +1 more source

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat

Neurobiology of Disease, 2006
Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia.
E.L. Lane, C. Winkler, P. Brundin, M.A. Cenci   +3 more
doaj   +1 more source

Subthalamic–pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia

, 2002
The subthalamic nucleus (STN) and external globus pallidus (GP) form a recurrent excitatory–inhibitory interaction within the basal ganglia. Through a computational model of these interactions we show that, under the influence of appropriate external ...
Willshaw, D., Zhaoping, L., Li, Z., Gillies, A.   +3 more
core   +1 more source