Results 41 to 50 of about 250,907 (309)

A biologically inspired computational model of the Block Copying Task [PDF]

, 2003
We present in this paper a biologically inspired model of the Basal Ganglia which deals with Block Copying as a sequence learning task. By breaking a relatively complex task into simpler operations with well-defined skills, an approach which is termed as
Arnold, Michael, Jabri, Marwan, Lan, Tian, Sejnowski, Terrence   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies

Acta Neuropathologica Communications, 2018
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic centres, basal ganglia and cerebellar ...
Violetta Refolo, Francesco Bez, Alexia Polissidis, Daniela Kuzdas-Wood, Edith Sturm, Martina Kamaratou, Werner Poewe, Leonidas Stefanis, M. Angela Cenci, Marina Romero-Ramos, Gregor K. Wenning, Nadia Stefanova   +11 more
doaj   +1 more source

Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device [PDF]

, 2005
Neurobehavioral data from intact, decerebrate, and neonatal rats, suggests that the reticular formation provides a brainstem substrate for action selection in the vertebrate central nervous system.
Baerends, G., Barto, A., Blumberg, B., Bowsher, D., Cherniak, C., Delwaide, P., Humphries, M., Jones, B., Kevin Gurney, Maes, P., Mark D. Humphries, Montes-Gonzalez, F., Newman, D., Scheibel, M., Stevens, D., Tony J. Prescott   +15 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The correlation between lateralization of intracerebral hemorrhage in basal ganglia and handedness [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To investigate the correlation between lateralization of cerebral basal ganglia hemorrhage and handedness. METHODS: Medical records and computed tomography (CT) scans for 84 patients with primary hypertensive intracerebral hemorrhage (ICH) in ...
Yu Cui, Zhenxing Zhang, Xiaochuan Huo, Jishou Dai, Guangrong Zheng, Xu Feng, Chao Wang   +6 more
doaj   +3 more sources

The causal interaction in human basal ganglia

Scientific Reports, 2021
The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified.
Clara Rodriguez-Sabate, Albano Gonzalez, Juan Carlos Perez-Darias, Ingrid Morales, Manuel Rodriguez   +4 more
doaj   +1 more source

How Laminar Frontal Cortex and Basal Ganglia Circuits Interact to Control Planned and Reactive Saccades [PDF]

, 2000
The basal ganglia and frontal cortex together allow animals to learn adaptive responses that acquire rewards when prepotent reflexive responses are insufficient.
Brown, Joshua, Bullock, Daniel, Grossberg, Stephen   +2 more
core   +1 more source

Childhood Adversity is Associated with Left Basal Ganglia Dysfunction During Reward Anticipation in Adulthood [PDF]

, 2009
Background: Childhood adversity increases the risk of psychopathology, but the neurobiological mechanisms underlying this vulnerability are not well-understood.
Anda, Anisman, Avram J. Holmes, Beck, Bjork, Blumenthal, Bremner, Cabib, Carlson, Chapman, Charney, Daniel G. Dillon, Deichmann, Diego A. Pizzagalli, Dillon, Dong, Drevets, Dube, Dube, Epstein, Fawcett, First, Fischl, Frank, Gabbay, George, Gladstone, Guyer, Harkness, Heim, Jeffrey L. Birk, Kalinichev, Karlen Lyons-Ruth, Kaufman, Knutson, Lumley, Lyons-Ruth, Lyons-Ruth, Martin, Matthews, Meyer, Miller, Nancy Brooks, Navalta, Nelson, Norris, Pizzagalli, Pollak, Pryce, Radloff, Samanez-Larkin, Schott, Smith, Starkstein, Strauss, Tae, Teicher, Tomer, Vataja, Volkow, Watson, Widom, Willner   +62 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source