Results 41 to 50 of about 27,260,641 (372)
A biologically inspired computational model of the Block Copying Task [PDF]
, 2003 We present in this paper a biologically inspired model of the Basal Ganglia which deals with Block Copying as a sequence learning task. By breaking a relatively complex task into simpler operations with well-defined skills, an approach which is termed as
Arnold, Michael +3 more
core
A hypothesis on improving foreign accents by optimizing variability in vocal learning brain circuits [PDF]
, 2015 Rapid vocal motor learning is observed when acquiring a language in early childhood, or learning to speak another language later in life. Accurate pronunciation is one of the hardest things for late learners to master and they are almost always left with
Simmonds, AJ
core +2 more sources
Acta Neuropathologica Communications, 2018 Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic centres, basal ganglia and cerebellar ...
Violetta Refolo +11 more
doaj +1 more source
Selection of cortical dynamics for motor behaviour by the basal ganglia [PDF]
, 2015 The basal ganglia and cortex are strongly implicated in the control of motor preparation and execution. Re-entrant loops between these two brain areas are thought to determine the selection of motor repertoires for instrumental action.
Baldassarre, Gianluca +1 more
core +1 more source
Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero +15 more
wiley +1 more source
Serotonin modulation of the basal ganglia circuitry : therapeutic implication for Parkinson’s disease and other motor disorders [PDF]
, 2008 Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia.
Benigno, Arcangelo +5 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau +12 more
wiley +1 more source
npj Parkinson's DiseaseDopamine replacement therapy for Parkinson’s disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining ...
Mirjam Wolfschlag +4 more
doaj +1 more source
The causal interaction in human basal ganglia
Scientific Reports, 2021 The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified.
Clara Rodriguez-Sabate +4 more
doaj +1 more source
How Laminar Frontal Cortex and Basal Ganglia Circuits Interact to Control Planned and Reactive Saccades [PDF]
, 2000 The basal ganglia and frontal cortex together allow animals to learn adaptive responses that acquire rewards when prepotent reflexive responses are insufficient.
Brown, Joshua +2 more
core +1 more source