Results 131 to 140 of about 117,087 (348)

Parkinsonism and Seizures in Fahr’s Disease: A Report of Two Cases

Journal of Clinical and Diagnostic Research
Fahr’s disease, also known as primary familial calcifications, is a rare neurodegenerative disorder characterised by abnormal calcium deposits in the brain caused by genetic mutations.
Bolisetty Shanmukha Sai, Tankasala Gangaram, Taruguvandla Sandhya Rani, Jennie Santhanam, SN Meenakshi Sundari   +4 more
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Leigh syndrome in an infant: autopsy and histopathology findings

Autopsy and Case Reports, 2021
Leigh syndrome is an inherited neurodegenerative disorder of infancy that typically manifests between 3 and 12 months of age. The common neurological manifestations are developmental delay or regression, progressive cognitive decline, dystonia, ataxia ...
Arushi Gahlot Saini, Debjyoti Chatterjee, Chandana Bhagwat, Sameer Vyas, Savita Verma Attri   +4 more
doaj  

Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. [PDF]

Neurosci Bull, 2020
Glaser T, Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Bonfim Marques L, Ye Q, Ren WJ, Semyanov A, Illes P, Tang Y, Ulrich H.   +10 more
europepmc   +1 more source

Control analysis of optogenetics and deep brain stimulation targeting basal ganglia for Parkinson's disease

, 2022
Honghui Zhang, Yuzhi Zhao, Zhuan Shen, Fangyue Chen, Zilu Cao, Wenxuan Shan   +5 more
openalex   +1 more source

Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology [PDF]

, 2021
Natália Pessoa Rocha, Odelin Charron, Leigh B. Latham, Gabriela Delevati Colpo, Paolo Zanotti‐Fregonara, Meixiang Yu, Léorah Freeman, Erin Furr Stimming, Antônio Lúcio Teixeira   +8 more
openalex   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease [PDF]

, 2016
Michal Rolinski, Ludovica Griffanti, Paola Piccini, Andreas–Antonios Roussakis, Konrad Szewczyk‐Królikowski, Ricarda Menke, Timothy Quinnell, Zenobia Zaiwalla, Johannes Klein, Clare E. Mackay, Michele T. M. Hu   +10 more
openalex   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington’s disease [PDF]

, 2023
Chin-Fu Liu, Laurent Younès, Xiao Tong, Jared T. Hinkle, Maggie Haitian Wang, Sanika Phatak, Xin Xu, Xuan Bu, Vivian Looi, Jee Bang, Sarah J. Tabrizi, Rachael I. Scahill, Jane S. Paulsen, Nellie Georgiou‐Karistianis, Andréia V. Faria, Michael I. Miller, J. Tilak Ratnanather, Christopher A. Ross   +17 more
openalex   +1 more source