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Athymhormia and Disorders of Motivation in Basal Ganglia Disease
Journal of Neuropsychiatry, 2004The author proposes a general model of human motivation as a separate function at the interface between emotion and action, which can be ascribed to subcortical circuits that are mainly centered on a subset of the basal ganglia and on their limbic connections.
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Apoptosis in Degenerative Diseases of the Basal Ganglia
The Neuroscientist, 1998Degenerative disorders of the basal ganglia are characterized by disturbances of motor control. Prototypic examples are Parkinson's disease, which is caused by degeneration of dopamine neurons of the substantia nigra, and Huntington's disease, which is caused by degeneration of neurons of the striatum. In recent years, it has been postulated that some
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Neuropsychiatry of Huntington’s Disease and Other Basal Ganglia Disorders
Psychosomatics, 2000Degenerative diseases of the basal ganglia, such as Huntington's disease (HD), Parkinson's disease, and Wilson's disease, are characterized by motor, cognitive, and psychiatric manifestations. HD, in particular, can be considered a paradigmatic neuropsychiatric disorder that has all three components of the "Triadic Syndromes": dyskinesia, dementia, and
Rosenblatt, A, Leroi, I.
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Functional changes of the basal ganglia circuitry in Parkinson's disease
Progress in Neurobiology, 2000The basal ganglia circuitry processes the signals that flow from the cortex, allowing the correct execution of voluntary movements. In Parkinson's disease, the degeneration of dopaminergic neurons of the substantia nigra pars compacta triggers a cascade of functional changes affecting the whole basal ganglia network.
F. Blandini +3 more
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Functional segregation of basal ganglia pathways in Parkinson’s disease
Brain, 2018Dopamine exerts modulatory signals on cortex-basal ganglia circuits to enable flexible motor control. Parkinson's disease is characterized by a loss of dopaminergic innervation in the basal ganglia leading to complex motor and non-motor symptoms. Clinical symptom alleviation through dopaminergic medication and deep brain stimulation in the subthalamic ...
Patricia Krause +11 more
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ATROPHY OF BASAL GANGLIA IN PICK'S DISEASE
Archives of Neurology & Psychiatry, 1944Although several observers in recent years have commented on the occurrence of changes in parts of the central nervous system other than the cerebral cortex in the condition of symmetric cortical atrophy first described by Pick, most workers continue to emphasize the cortical changes in their evaluation of the clinical signs and symptoms.
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Endocannabinoids in basal ganglia circuits
Neurology, 2007Endocannabinoids are endogenous lipid messengers that bind the cannabinoid (CB) receptors. These receptors mediate the multiple behavioral effects of l -Δ9 tetrahydrocannabinol, the main psychoactive component of marijuana (cannabis). The endocannabinoid system has been implicated in a large variety of functions, including regulation of appetite and ...
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