Results 281 to 290 of about 365,960 (349)

Basal insulin analogues in type 1 diabetes - Does one size fit all? Lessons from the HypoDeg trial based on single-patient outcomes. [PDF]

Heliyon
Hjejle S, Agesen RM, Thorsteinsson B, Pedersen-Bjergaard U, Brøsen JMB.   +4 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Correction: Regimen comprising GLP‑1 receptor agonist and basal insulin can decrease the effect of food on glycemic variability compared to a pre‑mixed insulin regimen. [PDF]

Eur J Med Res
Lin YH, Lin CH, Huang YY, Chen HY, Tai AS, Fu SC, Hsieh SH, Sun JH, Chen ST, Lin SH.   +9 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

No evidence of increased hypoglycaemia attributed to physical activity with once-weekly insulin icodec versus once-daily basal insulin degludec in type 1 diabetes: A post hoc analysis of ONWARDS 6. [PDF]

Diabetes Obes Metab
Sourij H, Bracken RM, Carstensen L, Pagliaro Rocha TM, Kehlet Watt S, Philis-Tsimikas A.   +5 more
europepmc   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study. [PDF]

Diabetes Obes Metab
Chen L, Wan H, Han J, Yang C, Shao H, Li J, Yan W, Xiao J, Sun Y, Li M, Han Y, Kang L, Zhang M.   +12 more
europepmc   +1 more source

Isoproterenol modulates insulin activation of insulin receptor kinase in intact rat adipocytes [PDF]

, 1988
Klein, H. H., Matthaei, S., Scriba, Peter Christian   +2 more
core  

Persistence to Basal Insulin: Association With Health Outcomes in a Population With Type 2 Diabetes. [PDF]

Clin Diabetes
Nsiah I, Campbell PJ, Parikh MA, Hines LE, Pickering M, Nau DP.   +5 more
europepmc   +1 more source