Results 21 to 30 of about 365,960 (349)

Management and efficacy of intensified insulin therapy starting in outpatients [PDF]

, 1989
Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients.
A Marble, A Schiffrin, AS Berger, B. Allolio, C Rosak, E Roth, EA Chantelau, FA Capper, FW Whitehouse, G. Ollenschläger, HJ Krönke, KF Hanssen, L Sachs, M Berger, M. Reincke, M. Steffen, P Heinze, RA Rizza, RM Wilson, RR Holman, The DCCT Research Group, V Jörgens, W Spuck, W. Hummerich, W. Winkelmann   +24 more
core   +1 more source

Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial [PDF]

, 2014
Introduction Evening-time exercise is a frequent cause of severe hypoglycemia in type 1 diabetes, fear of which deters participation in regular exercise.
Campbell, Matthew, Walker, Mark, Bracken, Richard, Turner, David, Stevenson, Emma, Gonzalez, Javier, Shaw, James, West, Dan   +7 more
core   +4 more sources

Constitutively Active CaMKKα Stimulates Skeletal Muscle Glucose Uptake in Insulin-Resistant Mice In Vivo [PDF]

, 2013
In insulin-sensitive skeletal muscle, the expression of constitutively active Ca(2+)/calmodulin-dependent protein kinase kinase α (caCaMKKα) stimulates glucose uptake independent of insulin signaling (i.e., Akt and Akt-dependent TBC1D1/TBC1D4 ...
Beck Jorgensen, Bjornholm, C. A. S. Smith, C. A. Witczak, DeFronzo, Enslen, Ferr  , J. J. Brault, J. L. Ferey, J. M. Hinkley, Kennedy, Kramer, L. A. A. Gilliam, Surwit, Surwit, Towbin, Treebak, Vichaiwong, Wright, Yano   +19 more
core   +1 more source

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

Switching from basal or basal-bolus insulin to biphasic insulin aspart 30: Results from the Indian cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2014
Aim: To determine the safety and efficacy of biphasic insulin aspart 30 (BIAsp 30) therapy in the Indian patients with type 2 diabetes previously on basal or basal-bolus insulin therapies.
Arpandev Bhattacharyya, Raman Shetty, C Rajkumar, Ganapathi Bantwal   +3 more
doaj   +1 more source

Analysis of insulin doses of Chinese type 2 diabetic patients with intensive insulin treatment. [PDF]

PLoS ONE, 2012
BackgroundTo investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.Methodology/principal findingsTotally 2480 patients prescribed with pre ...
Xiaoling Cai, Xueyao Han, Yingying Luo, Linong Ji   +3 more
doaj   +1 more source

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]

, 2012
Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun, Devaskar, Sherin U, Garg, Meena, Shin, Bo-Chul, Stout, David, Thamotharan, Manikkavasagar, Thamotharan, Shanthie   +6 more
core   +1 more source

Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. [PDF]

, 2017
Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce ...
Hay, William W, Lee, Samuel, Nguyen, Amanda, Qiao, Liping, Schaack, Jerome, Shao, Jianhua, Wattez, Jean-Sebastien   +6 more
core   +1 more source

Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]

, 2015
Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J., Gould, Gwyn W., Kioumourtzoglou, Dimitrios, Pryor, Paul R.   +3 more
core   +3 more sources