Results 31 to 40 of about 365,960 (349)

Basal insulin analogues in the treatment of diabetes mellitus: What progress have we made?

Indian Journal of Endocrinology and Metabolism, 2015
Over the past few decades, continuous progress has been made in the development of insulin therapy. Basal insulins were developed around 60 years ago. However, existing basal insulins were found to have limitations. An ideal basal insulin should have the
Sanjay Kalra
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Modern basal insulin analogs: An incomplete story

Indian Journal of Endocrinology and Metabolism, 2014
The currently available basal insulin does not completely mimic the endogenous insulin secretion. This has continued to promote the search for ideal basal insulin.
Awadhesh Kumar Singh, Kalyan Kumar Gangopadhyay   +1 more
doaj   +1 more source

Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care

Annals of Medicine, 2021
Many patients with type 2 diabetes will ultimately require the inclusion of basal insulin in their treatment regimen. Since most people with type 2 diabetes are managed in the community, it is important that primary care providers understand and ...
Roopa Mehta, Ronald Goldenberg, Daniel Katselnik, Louis Kuritzky   +3 more
doaj   +1 more source

Dynamic Insulin Basal Needs Estimation and Parameters Adjustment in Type 1 Diabetes

Sensors, 2021
Technology advances have made possible improvements such as Continuous Glucose Monitors, giving the patient a glucose reading every few minutes, or insulin pumps, allowing more personalized therapies.
Jesús Berián, Ignacio Bravo, Alfredo Gardel-Vicente, José-Luis Lázaro-Galilea, Mercedes Rigla   +4 more
doaj   +1 more source

Comparison of insulin detemir and insulin glargine in a Basal-Bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, treat-to-target noninferiority trial [PDF]

, 2009
Objective: The primary study objective was to determine whether insulin detemir (detemir) was noninferior to insulin glargine (glargine) as the basal insulin in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in terms of glycemic ...
Albright, Bolli, Bruce Bode, Buse, Christoph Koenen, Devries, Garg, Havelund, Heinemann, Heinemann, Heise, Heise, Hermansen, Hougaard, Jehle, Klein, Le Floch, Montgomery, Owens, Pieber, Ratner, Russell-Jones, Simon Heller   +22 more
core   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter, Fottner, Christian, Simmler, Pia, Weber, Matthias M.   +3 more
core   +1 more source

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism [PDF]

, 2016
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis.
Abruzzese, Giselle Adriana, Ferreira, Silvana Rocío, Heber, María Florencia, Motta, Alicia Beatriz, Pignataro, Omar Pedro, Reynoso, Roxana María, Velez, Leandro Martin   +6 more
core   +2 more sources

Comparison of the Effect of Glycemic Control in Type 2 Diabetes Outpatients Treated With Premixed and Basal Insulin Monotherapy in China

Frontiers in Endocrinology, 2018
Background: Basal and premixed insulin have been widely used for insulin therapy of type 2 diabetes mellitus (T2DM) in China. The aim of this study is to compare the sustained efficacy of basal and premixed insulin therapies in T2DM outpatients with ...
Guangxu Liu, Guangxu Liu, Jingtao Dou, Jingtao Dou, Yuesong Pan, Yuesong Pan, Yuxiang Yan, Yuxiang Yan, Huiping Zhu, Huiping Zhu, Juming Lu, Herbert Gaisano, Linong Ji, Yan He, Yan He   +14 more
doaj   +1 more source