Results 181 to 190 of about 348,538 (259)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Dietary sublancin or oregano essential oil enhances growth and immunity in goat kids via modulating colonic microbiota and bile acids. [PDF]

Anim Nutr
Tao W, Xu L, Yang R, Sun C, Yu A, Xie Y, Liu Z, Zhang X, Guo B, Fu S, Yao Q, Liang Y, Hu J, Liu W, Lei Z.   +14 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Effects of fermented palm kernel cake on growth performance, intestinal health, cecal microbiota, and ammonia emission in broilers. [PDF]

Poult Sci
Li J, Chen Z, Huang R, Liu Z, Yan C, Zhan X, Xu Y, Wang Y, Lan Y, Zhang X, Wang Y.   +10 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Spatially-resolved subtype progression reveals metabolic vulnerabilities in pancreatic ductal adenocarcinoma. [PDF]

Mol Cancer
Schmitt AM, Gätje FB, Tran MYR, Midelashvili T, Xu X, Fleischer JR, Spahn H, Lai K, Tacke T, Younes S, Mittlmeier A, Schulze O, Hasanovic K, Blume ML, Rotter SM, Tesch TR, Schneider C, Todorovic J, Bohnenberger H, Kueffer S, Ströbel P, Papantonis A, Sax U, Agorku D, Rüberg S, Yassouri FE, Purushothaman R, Warratz S, Ferreira N, Schneider G, Igelmann S, Planque M, Fendt SM, Ghadimi M, Hessmann E, Ackermann L, De Oliveira T, Conradi LC.   +37 more
europepmc   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Chatterjee S, Sengupta S, Ghosh R, Benito-León J, Dubey S.   +4 more
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Dried persimmon peel as a sustainable feed ingredient for goats: Effects on nutrient digestion, energy-nitrogen metabolism, and methane mitigation. [PDF]

Anim Nutr
Zhang X, Yin Q, Hui J, Wu A, Zhu Y, Balasubramanian B, Ge G, Yang J, Liu Z, Deng L, Yao J, Lei X.   +11 more
europepmc   +1 more source