Results 191 to 200 of about 645,299 (299)

Spatially-resolved subtype progression reveals metabolic vulnerabilities in pancreatic ductal adenocarcinoma. [PDF]

Mol Cancer
Schmitt AM, Gätje FB, Tran MYR, Midelashvili T, Xu X, Fleischer JR, Spahn H, Lai K, Tacke T, Younes S, Mittlmeier A, Schulze O, Hasanovic K, Blume ML, Rotter SM, Tesch TR, Schneider C, Todorovic J, Bohnenberger H, Kueffer S, Ströbel P, Papantonis A, Sax U, Agorku D, Rüberg S, Yassouri FE, Purushothaman R, Warratz S, Ferreira N, Schneider G, Igelmann S, Planque M, Fendt SM, Ghadimi M, Hessmann E, Ackermann L, De Oliveira T, Conradi LC.   +37 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

<i>Allium mongolicum</i> Regel Ethanol Extract Remodels Plasma Metabolome and Lipid Metabolism While Modulating Milk Metabolite Profiles in Dairy Cows. [PDF]

Animals (Basel)
Bai C, Wang X, Han G, Cao Q, Zheng Y, Duan J, Li H, Ao C, Erdene K.   +8 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Dual-action peptide KWH₂ protects against Salmonella choleraesuis diarrhea in weaned piglets by enhancing intestinal barrier integrity and modulating GSK-3β/Myc signaling. [PDF]

Vet Res
Zhu Y, Lv K, Tian Z, Han Y, Bi Z, Dong N.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A unified ACSF3-mtFAS model linking mitochondrial energy metabolism to human anthropometric evolution. [PDF]

Cell Genom
Tucci S.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Transcriptomic Insights into Sre1-Related Regulatory Responses to Hypoxia, Cobalt Chloride, and Clotrimazole in <i>Phaffia rhodozyma</i>. [PDF]

J Fungi (Basel)
Baeza M, Gutiérrez MS, Gómez M, Alcaíno J.   +3 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source