Results 71 to 80 of about 1,675,267 (255)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Estimated Energy Requirement: Comparison Between the 2005 and 2023 Dietary Reference Intakes in Sedentary Adults and Older Adults—A Retrospective Cross-Sectional Study

Obesities
Background: Equations for estimating energy expenditure are developed for specific populations and contexts, including clinical settings, body composition variations, and age groups, to enhance precision in nutritional planning and health promotion ...
Anderson Matheus Oliveira Haas Verdi, Jaqueline Machado Soares, Jaqueline Fernandes Carneiro, Izadora Oliveira Felez, Dalton Luiz Schiessel, Daniele Gonçalves Vieira, Adriana Masiero Kühl, Daniela Caetano Gonçalves, Angelica Rocha de Freitas Melhem   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Testosterone Metabolism in Basal Cell Epitheliomas [PDF]

, 1978
In basal cell epitheliomas the testosterone metabolism pattern differs from that of the normal surrounding skin. There is a significant reduction in 5 alpha-reductase activity with a consequent decrease in production of dihydrotestosterone and ...
Rampini, E., Cardo, P., Pellerano, S., Moretti, G.   +3 more
core   +1 more source

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study

Molecular Metabolism, 2018
Objectives: The laboratory mouse is presently the most common model for examining mechanisms of human physiology and disease. Housing temperatures can have a large impact on the outcome of such experiments and on their translatability to the human ...
Alexander W. Fischer, Barbara Cannon, Jan Nedergaard   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Steroidogenic control of liver metabolism through a nuclear receptor-network [PDF]

, 2019
OBJECTIVE: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown.
Owen, Bryn M., Burgering, Boudewijn M.T., Massafra, Vittoria, Williamson, Catherine, Owen, Bryn M, Burgering, Boudewijn MT, van Mil, Saskia W.C., Vernia, Santiago, Paterson, Helen AB, Bosma, Piter, Willemsen, Ellen C. L., van Mil, Saskia W. C., van Mil, Saskia WC, Burgering, Boudewijn M. T., Ramos Pittol, Jose M, Bijsmans, Ingrid T.G.W., Artigas, Natalia, Bijsmans, Ingrid TGW, Willemsen, Ellen CL, Dhillo, Waljit S., Milona, Alexandra, Naik, Jyoti, Vos, Harmjan, Paterson, Helen A. B., Bijsmans, Ingrid T. G. W., Willemsen, Ellen C.L., Miguel-Aliaga, Irene, Ramos Pittol, Jose M., Paterson, Helen A.B., Dhillo, Waljit S   +29 more
core   +1 more source

Metabolic stress in patients with acute severe ulcerative colitis - a single-center cohort study

Frontiers in Endocrinology
Background and aimsAcute severe ulcerative colitis (ASUC) is characterized by systemic inflammation, which may initiate an acute-phase response leading to hypercatabolism.
Mathias Redsted, Mathias Redsted, Magnus Grønhøj, Magnus Grønhøj, Louise Dalsgaard Brøchner, Louise Dalsgaard Brøchner, Janne Fassov, Mads Vandsted Svart, Mads Vandsted Svart, Jens Rikardt Andersen, Christian Lodberg Hvas   +10 more
doaj   +1 more source

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

BMC Cancer, 2010
Background Increased concentrations of choline-containing compounds are frequently observed in breast carcinomas, and may serve as biomarkers for both diagnostic and treatment monitoring purposes.
Moestue Siver A, Borgan Eldrid, Huuse Else M, Lindholm Evita M, Sitter Beathe, Børresen-Dale Anne-Lise, Engebraaten Olav, Mælandsmo Gunhild M, Gribbestad Ingrid S   +8 more
doaj   +1 more source