Results 111 to 120 of about 163,433 (289)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Microbiological Indicators for Assessing the Effects of Agricultural Practices on Soil Health: A Review

Agronomy
Agricultural practices significantly impact soil properties and ecological functions, highlighting the importance of comprehensive soil health assessments.
Mikhail V. Semenov, Alena D. Zhelezova, Natalya A. Ksenofontova, Ekaterina A. Ivanova, Dmitry A. Nikitin, Vyacheslav M. Semenov   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Heightened mitochondrial respiration in CF cells is normalised by triple CFTR modulator therapy through mechanisms involving calcium

Heliyon
Background: Cystic fibrosis (CF) is associated with increased resting energy expenditure. However, the introduction of elexacaftor/tezacaftor/ivacaftor (ETI) has resulted in a paradigm shift in nutritional status for many people with CF, with increase ...
H.H. Jarosz-Griffiths, L.R. Caley, S. Lara-Reyna, S. Savic, I.J. Clifton, M.F. McDermott, D.G. Peckham   +6 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration

Cell Communication and Signaling
Abstract Background Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stages. Among all BC subtypes, triple-negative BC (TNBC) is the most challenging cancer subtype lacking effective molecular targets due to the ...
Prokakis, Evangelos, Bamahmoud, Husam, Jansari, Shaishavi, Fritsche, Lena, Dietz, Alexander, Boshnakovska, Angela, Rehling, Peter, Johnsen, Steven A., Gallwas, Julia, Wegwitz, Florian   +9 more
openaire   +4 more sources

Basal Respiration as a Proxy to Understand Spatial Trends in CO2 Emissions in the Moscow Region

RUDN Journal of Agronomy and Animal Industries, 2016
Soil respiration (Rs) is an important terrestrial CO2 efflux and receives significant attention at different scale levels. However, the sampling density is limited and global Rs databases are biased towards natural ecosystems. Urbanization is among the most important current land-use trends and its role will likely grow in the future. Urban soils store
VASENEV V.I., STOORVOGEL J.J., PLYUSHCHIKOV V.G., ANANYEVA N.D., IVASHCHENKO K.V., ROMZAYKINA O.N.   +5 more
openaire   +4 more sources

In Vitro Antioxidant Effects of Coenzyme Q10 on Cellular Metabolism in Aged Mesenchymal Stem Cells

Applied Sciences
(1) Background: this study investigates the short-term effects of coenzyme Q10 (CoQ10) on mitochondrial respiration, fatty acid metabolism, oxidative stress gene expression, and sirtuin activity in young (passage 5, P5) and aged (passage 16, P16 ...
Alexandra Ivan, Alexandra Teodora Lukinich-Gruia, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Crenguta Livia Calma, Andreea Paunescu, Calin Adrian Tatu, Atena Galuscan, Virgil Paunescu   +8 more
doaj   +1 more source

Effects of Ponderosa Pine Ecological Restoration on Forest Soils and Understory Vegetation in Northern Arizona [PDF]

, 2017
The human exclusion of wildfire and overgrazing by livestock since settlement have caused dramatic changes in ponderosa pine (Pinus ponderosa Dougl ex Laws) forest ecosystems.
Abella, Scott R, Farrish, Kenneth W, Oswald, Brian P., Shaw-Faulkner, Melinda G., Thomas, Elena M   +4 more
core   +1 more source