Results 1 to 10 of about 645,590 (301)

Age-Dependent Alterations in Platelet Mitochondrial Respiration

Biomedicines, 2023
Mitochondrial dysfunction is an important cellular hallmark of aging and neurodegeneration. Platelets are a useful model to study the systemic manifestations of mitochondrial dysfunction.
Zdeněk Fišar, Jana Hroudová, Martina Zvěřová, Roman Jirák, Jiří Raboch, Eva Kitzlerová   +5 more
doaj   +2 more sources

Acute and prolonged effects of anti-malarial drugs on mitochondrial respiration in atrial cardiomyocytes for cardiac safety evaluation. [PDF]

PLoS ONE
ObjectivesMalaria is a global public health problem, causing significant morbidity and mortality, particularly in low and middle-income countries (LMICs).
Rahme Nese Safakli, Bonn Lee, Karan R Chadda, Savithri Sathivelu, Ioannis Smyrnias, Christopher L H Huang, Joel Tarning, Cesare Terracciano, Gary Tse, Charlotte E Edling, Kamalan Jeevaratnam   +10 more
doaj   +3 more sources

Analysis of oxygen consumption rates in zebrafish reveals differences based on sex, age and physical activity recovery

Frontiers in Physiology, 2023
Introduction: Mitochondrial dysfunction is linked to a variety of human diseases. Understanding the dynamic alterations in mitochondrial respiration at various stages of development is important to our understanding of disease progression.
Bridget Konadu, Jonathan P. Hosler, Yann Gibert, Kristin S. Edwards, Kristin S. Edwards   +4 more
doaj   +1 more source

FKBP4 regulates 5-fluorouracil sensitivity in colon cancer by controlling mitochondrial respiration

Life Science Alliance, 2022
FKBP4 controls mitochondrial respiration via modulating COA6-mediated biogenesis and activity of mitochondrial complex IV, thereby regulating 5-fluorouracil sensitivity in colon cancer.
Zhenyu Zhu, Qingsheng Hou, Bishi Wang, Changhao Li, Luguang Liu, Weipeng Gong, Jie Chai, Hongliang Guo, Yanhan Jia   +8 more
doaj   +1 more source

How to Measure Mitochondrial Oxygen Respiration [PDF]

운동과학, 2023
PURPOSE With the widespread of mitochondrial function, the need to accurately quantify and comprehend mitochondrial O2 respiration has gained prominence within the physiological and pathological spheres.
Jun-Won Heo, Eun-Jeong Cho, Youngju Choi, Dae Yun Seo, Jin Han, Dong-Ho Park, Ju-Hee Kang, Hyo-Bum Kwak   +7 more
doaj   +1 more source

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Molecular Metabolism, 2022
Objective: Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with ...
Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace   +8 more
doaj   +1 more source

Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function. [PDF]

PLoS ONE, 2014
The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators and underlie the enhancement of mitochondrial function described in the later phase of sepsis ...
Fredrik Sjövall, Saori Morota, Eleonor Åsander Frostner, Magnus J Hansson, Eskil Elmér   +4 more
doaj   +3 more sources

A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise

Scientific Reports, 2023
A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes mitochondrial respiration and attenuates mitochondrial oxidative stress in cultured cardiomyocytes.
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Belend Mahmoud, Albert Gerding, Justina C. Wolters, Anouk H. G. Wolters, Ben N. G. Giepmans, Herman H. W. Silljé, Rudolf A. de Boer, Barbara M. Bakker, B. Daan Westenbrink   +10 more
doaj   +1 more source

Invasive and noninvasive markers of human skeletal muscle mitochondrial function

Physiological Reports, 2023
Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninvasive markers ...
Rodrigo Mancilla, Diego Pava‐Mejia, Nynke vanPolanen, Vera deWit, Maaike Bergman, Lotte Grevendonk, Johanna Jorgensen, Esther Kornips, Joris Hoeks, Matthijs K. C. Hesselink, Vera B. Schrauwen‐Hinderling   +10 more
doaj   +1 more source

Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. [PDF]

PLoS ONE, 2012
During sepsis, liver dysfunction is common, and failure of mitochondria to effectively couple oxygen consumption with energy production has been described.
Siamak Djafarzadeh, Madhusudanarao Vuda, Jukka Takala, Stephan M Jakob   +3 more
doaj   +1 more source