Results 31 to 40 of about 645,590 (301)

Dose response of endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. [PDF]

, 2015
INTRODUCTION Results on mitochondrial dysfunction in sepsis are controversial. We aimed to assess effects of LPS at wide dose and time ranges on hepatocytes and isolated skeletal muscle mitochondria. METHODS Human hepatocellular carcinoma cells (
Stephan M. Jakob, Jakob, Stephan, Siamak Djafarzadeh, Brandt, Sebastian, Jukka Takala, Djafarzadeh, Siamak, Sebastian Brandt, Porta, Francesca, Takala, Jukka, Victor Jeger, Jeger, Victor, Francesca Porta, Jakob SM, Jeger V, Brandt S, Takala J, Djafarzadeh S, Porta F   +17 more
core   +2 more sources

Mitochondrial Respiration in Response to Iron Deficiency Anemia: Comparison of Peripheral Blood Mononuclear Cells and Liver

Metabolites, 2022
Iron is an essential component for metabolic processes, including oxygen transport within hemoglobin, tricarboxylic acid (TCA) cycle activity, and mitochondrial energy transformation.
Christine Fischer, Lara Valente de Souza, Timea Komlódi, Luiz F. Garcia-Souza, Chiara Volani, Piotr Tymoszuk, Egon Demetz, Markus Seifert, Kristina Auer, Richard Hilbe, Natascha Brigo, Verena Petzer, Malte Asshoff, Erich Gnaiger, Günter Weiss   +14 more
doaj   +1 more source

Inhibition of mitochondrial respiration by phosphoenolpyruvate [PDF]

Archives of Biochemistry and Biophysics, 2011
The cytosolic factors that influence mitochondrial oxidative phosphorylation rates are relatively unknown. In this report, we examine the effects of phosphoenolpyruvate (PEP), a glycolytic intermediate, on mitochondrial function. It is reported here that in rat heart mitochondria, PEP delays the onset of state 3 respiration in mitochondria supplied ...
Nathan Baily, C, Cason, Roger W, Vadvalkar, Shraddha S, Matsuzaki, Satoshi, Humphries, Kenneth M   +4 more
openaire   +2 more sources

Human Influenza A Virus (IAV) Decreases Mitochondrial Respiration of Infected MDCK Cell [PDF]

Iranian Journal of Public Health, 2005
Studies of interaction between viruses and mitochondria have shown that they can affect the mitochondria and induce mitochondrial alterations. Sometimes this interaction leads to induction or inhibition of apoptosis in infected cells. Interaction between
M Derakhshan, GEN Kass, MJ Carter
doaj   +2 more sources

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function

Cell Reports, 2019
Summary: Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of mitochondrial respiration in Tregs remains elusive.
Zheng Fu, Jian Ye, Joseph W. Dean, John W. Bostick, Samuel E. Weinberg, Lifeng Xiong, Kristen N. Oliff, Zongming E. Chen, Dorina Avram, Navdeep S. Chandel, Liang Zhou   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle

Experimental Physiology
The effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine‐dependent phosphate shuttling was previously unknown.
Emily J. Ferguson, Lauren J. Pacitti, Justin Bureau, Callum J. Pufahl, Eveline Menezes, Tanner Stokes, Shivam Gandhi, Luca J. Delfinis, Craig A. Simpson, Christopher G. R. Perry, Brendon J. Gurd, Chris McGlory   +11 more
doaj   +1 more source

Data from: Reduced mitochondrial respiration in hybrid asexual lizards

, 2022
The scarcity of asexual reproduction in vertebrates alludes to an inherent cost. Several groups of asexual vertebrates exhibit lower endurance capacity (a trait predominantly sourced by mitochondrial respiration) compared to congeneric sexual species ...
Fujita, Matthew K., Yap, Kang Nian, Herron, Victoria A., Horne, L. Miles, Wolak, Matthew E., Oaks, Jamie R., Klabacka, Randy L., Schwartz, Tonia S., Cook, Ryan A., Maldonado, Jose A., Parry, Hailey A., Kavazis, Andreas N.   +11 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Improvement of Platelet Respiration by Cell–Permeable Succinate in Diabetic Patients Treated with Statins

Life, 2021
Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first–line lipid–lowering therapy in diabetic patients with or without a history
Vlad Florian Avram, Anca Mihaela Bîna, Alexandra Sima, Oana Maria Aburel, Adrian Sturza, Ovidiu Burlacu, Romulus Zorin Timar, Danina Mirela Muntean, Eskil Elmér, Octavian Marius Crețu   +9 more
doaj   +1 more source