Results 51 to 60 of about 1,809,757 (282)

Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont. [PDF]

PLoS Genetics, 2009
The genetic code relates nucleotide sequence to amino acid sequence and is shared across all organisms, with the rare exceptions of lineages in which one or a few codons have acquired novel assignments. Recoding of UGA from stop to tryptophan has evolved
John P McCutcheon, Bradon R McDonald, Nancy A Moran   +2 more
doaj   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The CpG Landscape of Protein Coding DNA in Vertebrates

Evolutionary Applications
DNA methylation has fundamental implications for vertebrate genome evolution by influencing the mutational landscape, particularly at CpG dinucleotides.
Justin J. S. Wilcox, James Ord, Dennis Kappei, Toni I. Gossmann   +3 more
doaj   +1 more source

Composite quantile‐based classifiers

Statistical Analysis and Data Mining: The ASA Data Science Journal, 2020
AbstractAccurate classification of high‐dimensional data is important in many scientific applications. We propose a family of high‐dimensional classification methods based upon a comparison of the component‐wise distances of the feature vector of a sample to the within‐class population quantiles.
David A. Pritchard, Yufeng Liu
openaire   +3 more sources

Compositional equivalences based on open pNets

Journal of Logical and Algebraic Methods in Programming, 2022
Establishing equivalences between programs or systems is crucial both for verifying correctness of programs, by establishing that two implementations are equivalent, and for justifying optimisations and program transformations, by establishing that a modified program is equivalent to the source one.
Ameur-Boulifa, Rabéa, Henrio, Ludovic, Madelaine, Eric   +2 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Base Composition and Translational Selection are Insufficient to Explain Codon Usage Bias in Plant Viruses

Viruses, 2013
Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases.
Siobain Duffy, Kate DeRosa, Daniel J. Cardinale   +2 more
doaj   +1 more source

Parameters of neonate serum acid-base state and gas composition in multifetal pregnancy

Акушерство, гинекология и репродукция, 2021
Aim: to study ABS parameters, blood gas composition and complete blood count in newborns upon multiple pregnancy depending on the order of twin birth, neonate weight, and accompanying chronic hypoxia. Materials and Methods. Laboratory parameters assessed
S. A. Kalashnikov
doaj   +1 more source