Results 41 to 50 of about 499,009 (308)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Coating with overlay metallic-cermet alloy systems [PDF]

, 1984
A base layer of an oxide dispersed, metallic alloy (cermet) is arc plasma sprayed onto a substrate, such as a turbine blade, vane, or the like, which is subjected to high temperature use.
Gedwill, M. A., Glasgow, T. K., Levine, S. R.   +2 more
core   +1 more source

Tectonic denudation and topographic development in the Spanish Sierra Nevada [PDF]

, 2007
The denudation history of the rapidly uplifting western part of the Spanish Sierra Nevada was assessed using apatite fission track (AFT) ages and 10Be analyses of bedrock and fluvial sediments.
Alfaro, Anhert, Argles, Avouac, Beck, Bierman, Bierman, Braga, Brown, Brozovic, Burbank, C. Persano, Calvache, Carrapa, Chamberlain, Codilean, Dempster, Dramis, Dunkl, Dunne, Edwards, England, Fabel, Fernández, Fifield, Gabet, Galindino-Zaldívar, Gallagher, García, Garzione, Gleadow, Gosse, Granger, Granger, Granger, Gómez, Gómez-Ortiz, Hodges, Hovius, Hovius, Hubbard, Hurford, Hurford, J. F. Shroder, Jalut, Johnson, Johnson, Kapp, Keller, Kirchner, Kohl, Kuhleman, L. J. Reinhardt, Lal, Li, Lonergan, Martínez-Martínez, McClay, Mérnard, Niemi, Platt, Platt, Reinhardt, Rey, Riebe, Rodríguez-Fernández, Roering, Sanz de Galdeano, Sanz de Galdeano, Savage, Schildgen, Schmidt, Shroder, Shroder, Simón, Small, Sorkhabi, Stone, Stroeven, Sánchez, Sánchez-Marañón, T. J. Dempster, Tucker, Tucker, Van Bemmelen, Vance, Whipple, Whipple   +87 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Dynamics of gully side erosion: a case study using tree roots exposure data

Open Geosciences, 2016
Erosion is a frequently studied natural process. Unfortunately, detailed analysis mostly requires longterm field monitoring or detailed digital elevation models (DEM) which are still absent for many areas.
Šilhán Karel, Ružek Ivan, Burian Libor   +2 more
doaj   +1 more source

Base-Level of Eolian Erosion [PDF]

The Journal of Geology, 1909
The recognition of a land-level coinciding very nearly with that of the surface of the sea, but below which stream-corrasion cannot go, is a concept which has had such a potent influence in molding opinion concerning land-sculpturing and its evolution that any exception or modification is yet to receive general approval.
openaire   +1 more source

Crater mound formation by wind erosion on Mars

, 2018
Most of Mars' ancient sedimentary rocks by volume are in wind-eroded sedimentary mounds, but the connections between mound form and wind erosion are unclear.
Kite, Edwin S., Michaels, Timothy I., Steele, Liam J.   +2 more
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source