Results 1 to 10 of about 20,403 (100)

Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions

open access: yesNon-Coding RNA, 2021
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation.
Ilias Skeparnias, Jinwei Zhang
doaj   +1 more source

Maternal Factor V Leiden Mutation in Preeclampsia: A Case-Control South Eastern Indian Tertiary Care Hospital Based Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2020
Introduction: Pre-Eclampsia (PE) is a pregnancy-specific disorder which further complicates and leads to eclampsia. The Factor V Leiden (FVL) is an autosomal dominant genetic abnormality with incomplete penetrance predisposes to thrombosis.
Krishnaveni Changalvala   +6 more
doaj   +1 more source

SS/SW BASE PAIRS ARE THE ONLY BASE PAIRS INVOLVED IN LONG-RANGE RNA TERTIARY MOTIFS

open access: yesJournal of Bioinformatics and Genomics, 2020
The structure of noncoding RNAs largely determines their functions. With the rapid growth of experimental data on the RNA secondary structures, the task of predicting its spatial structure becomes the most urgent task of RNA bioinformatics.
Manakov, A.K.   +2 more
doaj   +1 more source

A Quantum-Mechanical Looking Behind the Scene of the Classic G·C Nucleobase Pairs Tautomerization

open access: yesFrontiers in Chemistry, 2020
For the first time, at the MP2/6-311++G(2df,pd)//B3LYP/6-311++G(d,p) level of theory, a comprehensive quantum-mechanical investigation of the physico-chemical mechanism of the tautomeric wobblization of the four biologically-important G·C nucleobase ...
Ol'ha O. Brovarets'   +3 more
doaj   +1 more source

Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs. [PDF]

open access: yesPLoS Computational Biology, 2017
Prediction of RNA tertiary structure from sequence is an important problem, but generating accurate structure models for even short sequences remains difficult.
Michael F Sloma, David H Mathews
doaj   +1 more source

Calculating Distortions of Short DNA Duplexes with Base Pairing Between an Oxidatively Damaged Guanine and a Guanine

open access: yesMolecules, 2014
DNA is constantly being oxidized, and oxidized DNA is prone to mutation; moreover, guanine is highly sensitive to several oxidative stressors. Several oxidatively damaged forms of guanine—including 2,2,4-triamino-5(2H)-oxazolone (Oz), iminoallantoin (Ia),
Masayo Suzuki   +4 more
doaj   +1 more source

Effects of osmolytes and macromolecular crowders on stable GAAA tetraloops and their preference for a CG closing base pair [PDF]

open access: yesPeerJ, 2018
Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo.
Kaethe N. Leonard, Joshua M. Blose
doaj   +2 more sources

DNA-Directed Base Pair Opening

open access: yesMolecules, 2012
Strand separation is a fundamental molecular process essential for the reading of the genetic information during DNA replication, transcription and recombination.
Youri Timsit
doaj   +1 more source

Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDHIAI*4

open access: yesHuman Genomics, 2009
This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (ALDHIAI) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped.
Moore Shelley M   +5 more
doaj   +1 more source

Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases

open access: yesNature Communications, 2023
Rational design of self-assembled DNA nanostructures has become one of the fastest-growing research areas in molecular science. Particular attention is focused on the development of dynamic DNA nanodevices whose configuration and function are regulated ...
Yusuke Takezawa   +6 more
doaj   +1 more source

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