Results 21 to 30 of about 446,496 (303)
Maternal Factor V Leiden Mutation in Preeclampsia: A Case-Control South Eastern Indian Tertiary Care Hospital Based Study [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Pre-Eclampsia (PE) is a pregnancy-specific disorder which further complicates and leads to eclampsia. The Factor V Leiden (FVL) is an autosomal dominant genetic abnormality with incomplete penetrance predisposes to thrombosis.
Krishnaveni Changalvala +6 more
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The RNA Base-Pairing Problem and Base-Pairing Solutions [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 RNA molecules are folded into structures and complexes to perform a wide variety of functions. Determination of RNA structures and their interactions is a fundamental problem in RNA biology. Most RNA molecules in living cells are large and dynamic, posing unique challenges to structure analysis.
Zhipeng Lu, Howard Y. Chang
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Schiff base-mediated base pairing [PDF]
Nucleic Acids Symposium Series, 2005 We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). The formation of Schiff base remarkably increases thermal stability of the duplex DNA, whereas it completely dissociates upon heating at 90 degrees C. Neither AmC nor fU produces covalent linkage with other natural bases,
Chikara, Dohno +2 more
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RNAStructViz: graphical base pairing analysis [PDF]
Bioinformatics, 2021 Abstract Summary We present a new graphical tool for RNA secondary structure analysis. The central feature is the ability to visually compare/contrast up to three base pairing configurations for a given sequence in a compact, standardized circular arc diagram layout.
Maxie Dion Schmidt +2 more
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SS/SW BASE PAIRS ARE THE ONLY BASE PAIRS INVOLVED IN LONG-RANGE RNA TERTIARY MOTIFS
Journal of Bioinformatics and Genomics, 2020 The structure of noncoding RNAs largely determines their functions. With the rapid growth of experimental data on the RNA secondary structures, the task of predicting its spatial structure becomes the most urgent task of RNA bioinformatics.
Manakov, A.K. +2 more
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A Quantum-Mechanical Looking Behind the Scene of the Classic G·C Nucleobase Pairs Tautomerization
Frontiers in Chemistry, 2020 For the first time, at the MP2/6-311++G(2df,pd)//B3LYP/6-311++G(d,p) level of theory, a comprehensive quantum-mechanical investigation of the physico-chemical mechanism of the tautomeric wobblization of the four biologically-important G·C nucleobase ...
Ol'ha O. Brovarets' +3 more
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Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs. [PDF]
PLoS Computational Biology, 2017 Prediction of RNA tertiary structure from sequence is an important problem, but generating accurate structure models for even short sequences remains difficult.
Michael F Sloma, David H Mathews
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Molecules, 2014 DNA is constantly being oxidized, and oxidized DNA is prone to mutation; moreover, guanine is highly sensitive to several oxidative stressors. Several oxidatively damaged forms of guanine—including 2,2,4-triamino-5(2H)-oxazolone (Oz), iminoallantoin (Ia),
Masayo Suzuki +4 more
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Effects of osmolytes and macromolecular crowders on stable GAAA tetraloops and their preference for a CG closing base pair [PDF]
PeerJ, 2018 Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo.
Kaethe N. Leonard, Joshua M. Blose
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DNA-Directed Base Pair Opening
Molecules, 2012 Strand separation is a fundamental molecular process essential for the reading of the genetic information during DNA replication, transcription and recombination.
Youri Timsit
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