Results 31 to 40 of about 446,496 (303)
Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine
Molecules, 2012 DNA is constantly exposed to endogenous and exogenous oxidative stresses. Damaged DNA can cause mutations, which may increase the risk of developing cancer and other diseases. G:C-C:G transversions are caused by various oxidative stresses. 2,2,4-Triamino-
Hiroshi Miyazawa +5 more
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Identification of a novel cytosolic aldehyde dehydrogenase allele,
Human Genomics, 2009 This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (ALDHIAI) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped.
Moore Shelley M +5 more
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A Porphyrin-DNA Chiroptical Molecular Ruler With Base Pair Resolution
Frontiers in Chemistry, 2020 DNA-based molecular rulers enable scientists to determine important parameters across biology, from the measurement of protein binding interactions, to the study of membrane dynamics in cells.
Jonathan R. Burns +2 more
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Quantum Logic Gates Based on DNAtronics, RNAtronics, and Proteintronics
Advanced Intelligent Systems, 2021 Quantum computers (QCs) adopt an n‐state quantum mechanical system to manipulate the superposition state. However, molecular transistors are not used to build up the quantum logic gate.
Sheh-Yi Sheu, Hua-Yi Hsu, Dah-Yen Yang
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Characterization of the trans Watson-Crick GU base pair located in the catalytic core of the antigenomic HDV ribozyme. [PDF]
PLoS ONE, 2012 The HDV ribozyme's folding pathway is, by far, the most complex folding pathway elucidated to date for a small ribozyme. It includes 6 different steps that have been shown to occur before the chemical cleavage.
Dominique Lévesque +2 more
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Frontiers in Chemistry, 2019 Single nucleotide polymorphisms (SNPs) affect base pair stacking, which is the primary factor for maintaining the stability of DNA. However, the mechanism of how SNPs lead to phenotype variations is still unclear. In this work, we connected SNPs and base
Gen Li +6 more
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The base-pairing ability of the base pair-mimic nucleosides [PDF]
Nucleic Acids Symposium Series, 2007 The deoxyadenosine derivative tethering the phenyl group at N6 of deoxyadenosine (A(phe)) was previously found to have a property to stack strongly with adjacent nucleotide bases in a DNA duplex. On the other hand, it was also demonstrated that DNA polymerases selectively incorporated dTTP opposite A(phe) in a template DNA strand.
Shu-Ichi, Nakano +3 more
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Sequence-dependent base pair stepping dynamics in XPD helicase unwinding
eLife, 2013 Helicases couple the chemical energy of ATP hydrolysis to directional translocation along nucleic acids and transient duplex separation. Understanding helicase mechanism requires that the basic physicochemical process of base pair separation be ...
Zhi Qi +3 more
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iScience, 2022 Summary: Base pairs are fundamental building blocks of RNA. The base pairs of low stability are often critical in RNA functions. Here, we develop a solid-state NMR-based water-RNA exchange spectroscopy (WaterREXSY) to characterize RNA in solid.
Sha Zhao +10 more
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High Base Pair Opening Rates in Tracts of GC Base Pairs [PDF]
Journal of Biological Chemistry, 1999 Sequence-dependent structural features of the DNA double helix have a strong influence on the base pair opening dynamics. Here we report a detailed study of the kinetics of base pair breathing in tracts of GC base pairs in DNA duplexes derived from 1H NMR measurements of the imino proton exchange rates upon titration with the exchange catalyst ammonia.
U, Dornberger, M, Leijon, H, Fritzsche
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