Results 31 to 40 of about 20,403 (100)
Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing. [PDF]
PLoS ONE, 2016 We used targeted next generation deep-sequencing (Safe Sequencing System) to measure ultra-rare de novo mutation frequencies in the human male germline by attaching a unique identifier code to each target DNA molecule. Segments from three different human
Jordan Eboreime +4 more
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Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Journal of Nucleic Acids, 2011 Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano +2 more
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Hexameric helicase G40P unwinds DNA in single base pair steps
eLife, 2019 Most replicative helicases are hexameric, ring-shaped motor proteins that translocate on and unwind DNA. Despite extensive biochemical and structural investigations, how their translocation activity is utilized chemo-mechanically in DNA unwinding is ...
Michael Schlierf +3 more
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Significance of authenticity in meat and meat products in Iran
Iranian Journal of Health, Safety and Environment, 2014 The Authenticity of meat products is very important for religious and health reasons in Iran. According to legislation in Iran, the consumption and importation of pork, horse, donkey and cat products should be banned.
Tahereh Rezazadeh +2 more
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Molecules, 2012 Toward the expansion of the genetic alphabet, an unnatural base pair between 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds) and pyrrole-2-carbaldehyde (Pa) functions as a third base pair in replication and transcription, and provides a useful tool for the site-
Rie Kawai +4 more
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DNA calorimetric force spectroscopy at single base pair resolution
Nature CommunicationsDNA hybridization is a fundamental molecular reaction with wide-ranging applications in biotechnology. The knowledge of the temperature dependence of the thermodynamic parameters of duplex formation is crucial for quantitative predictions throughout the ...
P. Rissone +3 more
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TABASCO: A single molecule, base-pair resolved gene expression simulator
BMC Bioinformatics, 2007 Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior.
Endy Drew, Kelly Jason R, Kosuri Sriram
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iScience, 2022 Summary: Base pairs are fundamental building blocks of RNA. The base pairs of low stability are often critical in RNA functions. Here, we develop a solid-state NMR-based water-RNA exchange spectroscopy (WaterREXSY) to characterize RNA in solid.
Sha Zhao +10 more
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Molecular Dynamics Simulation of Homo-DNA: The Role of Crystal Packing in Duplex Conformation
Crystals, 2019 The (4′→6′)-linked DNA homolog 2′,3′-dideoxy-β-D-glucopyranosyl nucleic acid (dideoxy-glucose nucleic acid or homo-DNA) exhibits stable self-pairing of the Watson−Crick and reverse-Hoogsteen types, but does not ...
Jonathan H. Sheehan +4 more
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Structural prediction of RNA switches using conditional base-pair probabilities.
PLoS ONE, 2019 An RNA switch triggers biological functions by toggling between two conformations. RNA switches include bacterial riboswitches, where ligand binding can stabilize a bound structure.
Amirhossein Manzourolajdad +1 more
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