Results 31 to 40 of about 1,688,512 (279)

Dynamics of a bubble formed in double stranded DNA

open access: yes, 2008
We study the fluctuational dynamics of a tagged base-pair in double stranded DNA. We calculate the drift force which acts on the tagged base-pair using a potential model that describes interactions at base pairs level and use it to construct a Fokker ...
Kornberg A. Baker T. A.   +5 more
core   +1 more source

On base point free theorem for log canonical threefolds over the algebraic closure of a finite field [PDF]

open access: yes, 2015
We prove the base point free theorem for big line bundles on a three-dimensional log canonical projective pair defined over the algebraic closure of a finite field.Comment: 20 pages.
Martinelli, Diletta   +2 more
core   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

open access: yesFEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta   +3 more
wiley   +1 more source

Aviram-Ratner rectifying mechanism for DNA base pair sequencing through graphene nanogaps

open access: yes, 2012
We demonstrate that biological molecules such as Watson-Crick DNA base pairs can behave as biological Aviram-Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases.
Christian Wolowiec   +6 more
core   +1 more source

Base sequence dependent sliding of proteins on DNA [PDF]

open access: yes, 2004
The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered.
A. Travers   +7 more
core   +3 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

open access: yesFEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Self-organised criticality in base-pair breathing in DNA with a defect

open access: yes, 2011
We analyse base-pair breathing in a DNA sequence of 12 base-pairs with a defective base at its centre. We use both all-atom molecular dynamics (MD) simulations and a system of stochastic differential equations (SDE).
Ambjörnsson   +36 more
core   +1 more source

Free energy landscape and characteristic forces for the initiation of DNA unzipping [PDF]

open access: yes, 2015
DNA unzipping, the separation of its double helix into single strands, is crucial in modulating a host of genetic processes. Although the large-scale separation of double-stranded DNA has been studied with a variety of theoretical and experimental ...
Andricioaei, Ioan   +5 more
core   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Modeling DNA Structure, Elasticity and Deformations at the Base-pair Level

open access: yes, 2003
We present a generic model for DNA at the base-pair level. We use a variant of the Gay-Berne potential to represent the stacking energy between neighboring base-pairs.
A. Sarkar   +62 more
core   +1 more source

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