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Sequential CRISPR-EspCas9-Mediated Wild-Type Depletion Enhances the Detection Sensitivity of Rare Mutations for Canine Liquid Biopsy Application. [PDF]
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Pulling short DNA with mismatch base pairs
European Biophysics Journal, 2023Due to misincorporation during gene replication, the accuracy of the gene expression is often compromised. This results in a mismatch or defective pair in the DNA molecule (James et al. 2016). Here, we present our study of the stability of DNA with defects in the thermal and force ensembles. We consider DNA with a different number of defects from 2to16
Navin Singh, Nehal Mathur
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Dynamics of mismatched base pairs in DNA
Biochemistry, 1991The structural dynamics of mismatched base pairs in duplex DNA have been studied by time-resolved fluorescence anisotropy decay measurements on a series of duplex oligodeoxynucleotides of the general type d[CGG(AP)GGC].d[GCCXCCG], where AP is the fluorescent adenine analogue 2-aminopurine and X = T, A, G, or C.
C R, Guest +3 more
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Cytosine deamination in mismatched base pairs
Biochemistry, 1993The rate of deamination of cytosine in mismatched base pairs has been determined. Incubation of M13mp2 nicked heteroduplex DNA molecules containing T.C or C.C mispairs in the lacZ alpha-complementation gene results in deamination of cytosine to uracil, producing T.U or C.U mispairs. Strands which have undergone deamination at the target site to produce
L A, Frederico, T A, Kunkel, B R, Shaw
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Unique magnetic signatures of mismatched base pairs in DNA
The Journal of Chemical Physics, 2010Magnetic properties of DNA containing mispairs, such as different conformations of the G⋅A mispair, or a G⋅T mispair inserted into the DNA chain, have been theoretically investigated. The essential ingredients for these studies, the charge transfer integrals, were evaluated from the DNA sequences containing the mispair and optimized in the solvent.
Vadim, Apalkov +2 more
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Mismatched base pairing in RNA crystal structures
International Journal of Quantum Chemistry, 1999Non-Watson–Crick base pairs or mismatches in RNA crystal structures have been summarized and their effects on the geometry of RNA molecules and their biological implications have been discussed. The mismatches can distort the helical structures by producing kinks/bends and can increase or decrease the major groove width, depending on the sequence.
Baocheng Pan, Muttaiya Sundaralingam
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EFFECT OF MISMATCHED BASE PAIRS ON DNA PLECTONEMES
2022Base pair mismatches in DNA occur during replication and can result in mutations and certain types of cancer. The exact mechanism by which mismatch repair proteins recognize mismatches is still not well understood. Structures of mismatch recognition proteins bound to a mismatch indicate that the process involves introducing a sharp bend in the DNA and ...
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Electrical current through DNA containing mismatched base pairs
Nanotechnology, 2010Mismatched base pairs, such as different conformations of the G.A mispair, cause only minor structural changes in the host DNA molecule, thereby making mispair recognition an arduous task. Electron transport in DNA that depends strongly on the hopping transfer integrals between the nearest base pairs, which in turn are affected by the presence of a ...
Neranjan, Edirisinghe +3 more
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