Results 131 to 140 of about 32,528,266 (371)
Identifying RNA contacts from SHAPE-MaP by partial correlation analysis [PDF]
, 2014 In a recent paper Siegfried et al. published a new sequence-based structural RNA assay that utilizes mutational profiling to detect base pairing (MaP).
Doudna, Jennifer +2 more
core +3 more sources
Defects Can Increase the Melting Temperature of DNA-Nanoparticle Assemblies
, 2007 DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable ...
Harris, Nolan C., Kiang, Ching-Hwa
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MicroRNA: Biogenetic and Functional Mechanisms and Involvements in Cell Differentiation and Cancer
Journal of Pharmacological Sciences, 2006 .: MicroRNAs (miRNAs) are endogenous small noncoding RNAs (20 – 23 nucleotides) that negatively regulate the gene expressions at the posttranscriptional level by base pairing to the 3′ untranslated region of target messenger RNAs. Hundreds of miRNAs have
Tsuchiya Soken +2 more
doaj +1 more source
, 2003 Using Chandrasekhar's S-type coupling between rotational and intrinsic vortical modes one may simply reproduce the HFB dynamical properties of rotating nuclei within Routhian HF calculations free of pairing correlations yet constrained on the relevant so-
Laftchiev, H. +3 more
core +1 more source
Can re-entrance be observed in force induced transitions?
, 2009 A large conformational change in the reaction co-ordinate and the role of the solvent in the formation of base-pairing are combined to settle a long standing issue {\it i.e.} prediction of re-entrance in the force induced transition of DNA.
Bhattacharjee S. M. +11 more
core +1 more source
Wobble base-pairing slows in vivo translation elongation in metazoans.
RNA: A publication of the RNA Society, 2011 In the universal genetic code, most amino acids can be encoded by multiple trinucleotide codons, and the choice among available codons can influence position-specific translation elongation rates.
M. Stadler, A. Fire
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Cryptography, 2018 Attribute-based encryption (ABE) is used for achieving data confidentiality and access control in cloud environments. Most often ABE schemes are constructed using bilinear pairing which has a higher computational complexity, making algorithms inefficient
Balaji Chandrasekaran +1 more
doaj +1 more source
Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing
EMBO Journal, 2011 2′‐O‐methylation of eukaryotic ribosomal RNA (r)RNA, essential for ribosome function, is catalysed by box C/D small nucleolar (sno)RNPs. The RNA components of these complexes (snoRNAs) contain one or two guide sequences, which, through base‐pairing ...
R. V. van Nues +6 more
semanticscholar +1 more source