An ISFET Microarray Sensor System for Detecting the DNA Base Pairing [PDF]
Micromachines, 2021 Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy.
Peng Sun +5 more
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode [PDF]
Nature CommunicationsBy targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases.
Xiaoying Jia +19 more
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Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates [PDF]
Nature CommunicationsNature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively ...
Sumit Majumder +3 more
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Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity [PDF]
iScienceSummary: We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U
Tomislav Stolar +12 more
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A method for estimating energy parameters of RNAs by differentiating base-pairing probabilities. [PDF]
NAR Genom BioinformYamamura K, Terai G, Asai K.
europepmc +2 more sources
Force-Field-Dependent DNA Breathing Dynamics: A Case Study of Hoogsteen Base Pairing in A6-DNA. [PDF]
J Chem Inf Model, 2022 Stone SE, Ray D, Andricioaei I.
europepmc +3 more sources
The RNA Base-Pairing Problem and Base-Pairing Solutions [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 RNA molecules are folded into structures and complexes to perform a wide variety of functions. Determination of RNA structures and their interactions is a fundamental problem in RNA biology. Most RNA molecules in living cells are large and dynamic, posing unique challenges to structure analysis.
Zhipeng Lu, Howard Y. Chang
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Schiff base-mediated base pairing [PDF]
Nucleic Acids Symposium Series, 2005 We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). The formation of Schiff base remarkably increases thermal stability of the duplex DNA, whereas it completely dissociates upon heating at 90 degrees C. Neither AmC nor fU produces covalent linkage with other natural bases,
Chikara, Dohno +2 more
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Effect of Molecular Crowding on DNA Polymerase Reactions along Unnatural DNA Templates
Molecules, 2020 Unnatural nucleic acids are promising materials to expand genetic information beyond the natural bases. During replication, substrate nucleotide incorporation should be strictly controlled for optimal base pairing with template strand bases. Base-pairing
Shuntaro Takahashi +2 more
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Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition. [PDF]
PLoS Genetics, 2013 Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA ...
Edze R Westra +6 more
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