Sequence dependence of transient Hoogsteen base pairing in DNA. [PDF]
PLoS Computational Biology, 2022 Hoogsteen (HG) base pairing is characterized by a 180° rotation of the purine base with respect to the Watson-Crick-Franklin (WCF) motif. Recently, it has been found that both conformations coexist in a dynamical equilibrium and that several biological ...
Alberto Pérez de Alba Ortíz +2 more
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Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition. [PDF]
PLoS Genetics, 2013 Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA ...
Edze R Westra +6 more
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Controlling intermolecular base pairing in Drosophila germ granules by mRNA folding and its implications in fly development [PDF]
Nature CommunicationsDrosophila germ granules are enriched with mRNAs critical for development. Within them, mRNAs cluster through intermolecular interactions that may involve base pairing.
Siran Tian +5 more
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RNA base pairing complexity in living cells visualized by correlated chemical probing [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance How do we determine the structure of an RNA, particularly in cells? Chemical probing is a broadly applicable strategy for mapping RNA structure. However, chemical probing experiments do not observe base pairs directly and hence are unable to
Anthony M. Mustoe +4 more
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Unusual Base-Pairing Interactions in Monomer–Template Complexes
ACS Central Science, 2016 Many high-resolution crystal structures have contributed to our understanding of the reaction pathway for catalysis by DNA and RNA polymerases, but the structural basis of nonenzymatic template-directed RNA replication has not been studied in comparable ...
Wen Zhang +3 more
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RNAStructViz: graphical base pairing analysis. [PDF]
Bioinformatics, 2021 Abstract Summary We present a new graphical tool for RNA secondary structure analysis. The central feature is the ability to visually compare/contrast up to three base pairing configurations for a given sequence in a compact, standardized circular arc diagram layout.
Schmidt MD, Kirkpatrick A, Heitsch C.
europepmc +4 more sources
Physics of base-pairing dynamics in DNA [PDF]
, 2016 As a key molecule of Life, Deoxyribonucleic acid (DNA) is the focus of numbers of investigations with the help of biological, chemical and physical techniques.
Destainville, Nicolas, Manghi, Manoel
core +4 more sources
An ISFET Microarray Sensor System for Detecting the DNA Base Pairing [PDF]
Micromachines, 2021 Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy.
Peng Sun +5 more
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Spontaneous formation and base pairing of plausible prebiotic nucleotides in water
Nature Communications, 2016 One of the questions for prebiotic chemistry is the formation of complementary base pairing systems. Here, the authors show that plausible two prebiotic heterocycles can form glycosidic bonds with ribose in water and that these spontaneously base-pair in
Brian J. Cafferty +4 more
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode [PDF]
Nature CommunicationsBy targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases.
Xiaoying Jia +19 more
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