Hydrogen Bonding (Base Pairing) in Antiviral Activity [PDF]
Viruses, 2023 Base pairing based on hydrogen bonding has, since its inception, been crucial in the antiviral activity of arabinosyladenine, 2′-deoxyuridines (i.e., IDU, TFT, BVDU), acyclic nucleoside analogues (i.e., acyclovir) and nucleoside reverse transcriptase ...
Erik De Clercq
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Constraint of Base Pairing on HDV Genome Evolution [PDF]
Viruses, 2021 The hepatitis delta virus is a single-stranded circular RNA virus, which is characterized by high self-complementarity. About 70% of the genome sequences can form base-pairs with internal nucleotides.
Saki Nagata +2 more
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Watson‐Crick Base Pairing of N‐Methoxy‐1,3‐Oxazinane (MOANA) Nucleoside Analogues within Double‐Helical DNA [PDF]
ChemistryOpen, 2023 Hairpin oligodeoxynucleotides incorporating a (2R,3S)‐4‐(methoxyamino)butane‐1,2,3‐triol residue in the middle of the double‐helical stem and opposite to either one of the canonical nucleobases or an abasic 2‐(hydroxymethyl)tetrahydrofuran‐3‐ol spacer ...
Mark N. K. Afari +3 more
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Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position [PDF]
Molecules, 2017 Accurate translation of the genetic code depends on mRNA:tRNA codon:anticodon base pairing. Here we exploit an emissive, isosteric adenosine surrogate that allows direct measurement of the kinetics of codon:anticodon University of California base ...
Wei Liu +5 more
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Watson-Crick Base-Pairing Requirements for ssDNA Recognition and Processing in Replication-Initiating HUH Endonucleases [PDF]
mBio, 2023 Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication.
Adam T. Smiley +7 more
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Synthesis of 6-Alkynylated Purine-Containing DNA via On-Column Sonogashira Coupling and Investigation of Their Base-Pairing Properties [PDF]
Molecules, 2023 Synthetic unnatural base pairs have been proven to be attractive tools for the development of DNA-based biotechnology. Our group has very recently reported on alkynylated purine–pyridazine pairs, which exhibit selective and stable base-pairing via ...
Hidenori Okamura +4 more
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Sequence dependence of transient Hoogsteen base pairing in DNA. [PDF]
PLoS Computational Biology, 2022 Hoogsteen (HG) base pairing is characterized by a 180° rotation of the purine base with respect to the Watson-Crick-Franklin (WCF) motif. Recently, it has been found that both conformations coexist in a dynamical equilibrium and that several biological ...
Alberto Pérez de Alba Ortíz +2 more
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Controlling intermolecular base pairing in Drosophila germ granules by mRNA folding and its implications in fly development [PDF]
Nature CommunicationsDrosophila germ granules are enriched with mRNAs critical for development. Within them, mRNAs cluster through intermolecular interactions that may involve base pairing.
Siran Tian +5 more
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An ISFET Microarray Sensor System for Detecting the DNA Base Pairing [PDF]
Micromachines, 2021 Deoxyribonucleic acid (DNA) sequencing technology provides important data for the disclosure of genetic information and plays an important role in gene diagnosis and gene therapy.
Peng Sun +5 more
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode [PDF]
Nature CommunicationsBy targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases.
Xiaoying Jia +19 more
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