Results 21 to 30 of about 117,633 (252)
Identification of the base-pairing requirements for repression of hctA translation by the small RNA IhtA leads to the discovery of a new mRNA target in Chlamydia trachomatis. [PDF]
PLoS ONE, 2015 The non-coding small RNA, IhtA expressed by the obligate intracellular human pathogen Chlamydia trachomatis modulates the translation of HctA, a key protein involved in replicative to infectious cell type differentiation.
Nicole A Grieshaber +5 more
doaj +1 more source
Schiff base-mediated base pairing [PDF]
Nucleic Acids Symposium Series, 2005 We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). The formation of Schiff base remarkably increases thermal stability of the duplex DNA, whereas it completely dissociates upon heating at 90 degrees C. Neither AmC nor fU produces covalent linkage with other natural bases,
Chikara, Dohno +2 more
openaire +2 more sources
High Base Pair Opening Rates in Tracts of GC Base Pairs [PDF]
Journal of Biological Chemistry, 1999 Sequence-dependent structural features of the DNA double helix have a strong influence on the base pair opening dynamics. Here we report a detailed study of the kinetics of base pair breathing in tracts of GC base pairs in DNA duplexes derived from 1H NMR measurements of the imino proton exchange rates upon titration with the exchange catalyst ammonia.
U, Dornberger, M, Leijon, H, Fritzsche
openaire +2 more sources
Life, 2019 A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
doaj +1 more source
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation
eLife, 2020 By shaping gene expression profiles, small RNAs (sRNAs) enable bacteria to efficiently adapt to changes in their environment. To better understand how Escherichia coli acclimatizes to nutrient availability, we performed UV cross-linking, ligation and ...
Ira Alexandra Iosub +8 more
doaj +1 more source
Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position
Molecules, 2017 Accurate translation of the genetic code depends on mRNA:tRNA codon:anticodon base pairing. Here we exploit an emissive, isosteric adenosine surrogate that allows direct measurement of the kinetics of codon:anticodon University of California base ...
Wei Liu +5 more
doaj +1 more source
Pre-mRNA splicing is a determinant of nucleosome organization. [PDF]
PLoS ONE, 2013 Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed
Hadas Keren-Shaul +2 more
doaj +1 more source
Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation
Nature Communications, 2016 Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position ...
Franck Martin +8 more
doaj +1 more source
Uncovering Conceptual Biases in DNA Stabilization: A Student-Led Investigation
SpectrumThe structure of deoxyribonucleic acid (DNA) stands as one of the most foundational concepts in life sciences, essential for students to master. However, when surveyed about the forces that stabilize the double-stranded DNA structure, many students ...
Shawn Xiong +14 more
doaj +1 more source
Partition function and base pairing probabilities of RNA heterodimers
Algorithms for Molecular Biology, 2006 Background RNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function by binding to other nucleic acids, as in the case of microRNAs and snoRNAs.
Stadler Peter F +5 more
doaj +1 more source