Sequence dependence of transient Hoogsteen base pairing in DNA. [PDF]
PLoS Computational Biology, 2022 Hoogsteen (HG) base pairing is characterized by a 180° rotation of the purine base with respect to the Watson-Crick-Franklin (WCF) motif. Recently, it has been found that both conformations coexist in a dynamical equilibrium and that several biological ...
Alberto Pérez de Alba Ortíz +2 more
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Controlling intermolecular base pairing in Drosophila germ granules by mRNA folding and its implications in fly development [PDF]
Nature CommunicationsDrosophila germ granules are enriched with mRNAs critical for development. Within them, mRNAs cluster through intermolecular interactions that may involve base pairing.
Siran Tian +5 more
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode [PDF]
Nature CommunicationsBy targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases.
Xiaoying Jia +19 more
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Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates [PDF]
Nature CommunicationsNature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively ...
Sumit Majumder +3 more
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Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity [PDF]
iScienceSummary: We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U
Tomislav Stolar +12 more
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Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition. [PDF]
PLoS Genetics, 2013 Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA ...
Edze R Westra +6 more
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TurboFold: Iterative probabilistic estimation of secondary structures for multiple RNA sequences
BMC Bioinformatics, 2011 Background The prediction of secondary structure, i.e. the set of canonical base pairs between nucleotides, is a first step in developing an understanding of the function of an RNA sequence.
Sharma Gaurav +2 more
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Genome-wide double-stranded RNA sequencing reveals the functional significance of base-paired RNAs in Arabidopsis. [PDF]
PLoS Genetics, 2010 The functional structure of all biologically active molecules is dependent on intra- and inter-molecular interactions. This is especially evident for RNA molecules whose functionality, maturation, and regulation require formation of correct secondary ...
Qi Zheng +8 more
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Enzyme-free genetic copying of DNA and RNA sequences
Beilstein Journal of Organic Chemistry, 2018 The copying of short DNA or RNA sequences in the absence of enzymes is a fascinating reaction that has been studied in the context of prebiotic chemistry.
Marilyne Sosson, Clemens Richert
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Base Pairs to Populations [PDF]
Clinical Cancer Research, 2017 “There is much work to be done and many challenges exist in our mission to end the suffering that breast cancer brings.” So conclude Guest Editors Ann Partridge and Lisa Carey in their overview for this CCR Focus on breast cancer.
openaire +2 more sources