Results 21 to 30 of about 342,669 (235)
The RNA Base-Pairing Problem and Base-Pairing Solutions [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 RNA molecules are folded into structures and complexes to perform a wide variety of functions. Determination of RNA structures and their interactions is a fundamental problem in RNA biology. Most RNA molecules in living cells are large and dynamic, posing unique challenges to structure analysis.
Zhipeng Lu, Howard Y. Chang
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Pd2 +-mediated base pairing in oligonucleotides [PDF]
Journal of Inorganic Biochemistry, 2016 International audienceTwo short glycol nucleic acid (GNA) oligonucleotides, having either a terminal or an intrachain nucleobase replaced by the pyridine-2,6-dicarboxamide chelate of Pd2 +, have been synthesized and their hybridization properties studied
Golubev, Oleg +2 more
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RNAStructViz: graphical base pairing analysis [PDF]
Bioinformatics, 2021 Abstract Summary We present a new graphical tool for RNA secondary structure analysis. The central feature is the ability to visually compare/contrast up to three base pairing configurations for a given sequence in a compact, standardized circular arc diagram layout. This is complemented by a built-in
Maxie Dion Schmidt +2 more
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Base-pairing of uracil and 2,6-diaminopurine: from cocrystals to photoreactivity [PDF]
iScienceSummary: We show that the non-canonical nucleobase 2,6-diaminopurine (D) spontaneously base pairs with uracil (U) in water and the solid state without the need to be attached to the ribose-phosphate backbone. Depending on the reaction conditions, D and U
Tomislav Stolar +12 more
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Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates [PDF]
Nature CommunicationsNature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively ...
Sumit Majumder +3 more
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Base Pairing Promoted the Self-Organization of Genetic Coding, Catalysis, and Free-Energy Transduction [PDF]
LifeHow Nature discovered genetic coding is a largely ignored question, yet the answer is key to explaining the transition from biochemical building blocks to life. Other, related puzzles also fall inside the aegis enclosing the codes themselves. The peptide
Charles W. Carter
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Journal of Experimental and Molecular Biology, 2022 In contrast to Watson-Crick (WC) base pairing, Hoogsteen (HG) base pairing involves flipping a purine base 180° between its anti and syn conformation.
Neelabh Datta
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DNA-Mimicking Metal–Organic Frameworks with Accessible Adenine Faces for Complementary Base Pairing [PDF]
JACS Au, 2022 Santanu Chand +8 more
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The base-pairing ability of the base pair-mimic nucleosides [PDF]
Nucleic Acids Symposium Series, 2007 The deoxyadenosine derivative tethering the phenyl group at N6 of deoxyadenosine (A(phe)) was previously found to have a property to stack strongly with adjacent nucleotide bases in a DNA duplex. On the other hand, it was also demonstrated that DNA polymerases selectively incorporated dTTP opposite A(phe) in a template DNA strand.
Shu-ichi Nakano +3 more
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High Base Pair Opening Rates in Tracts of GC Base Pairs [PDF]
Journal of Biological Chemistry, 1999 Sequence-dependent structural features of the DNA double helix have a strong influence on the base pair opening dynamics. Here we report a detailed study of the kinetics of base pair breathing in tracts of GC base pairs in DNA duplexes derived from 1H NMR measurements of the imino proton exchange rates upon titration with the exchange catalyst ammonia.
Hartmut Fritzsche +2 more
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