Results 71 to 80 of about 117,633 (252)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Journal of Microbiology & Biology Education, 2011 Explaining base pairing is an important element in teaching undergraduate genetics. I propose a teaching approach that aims to close the gap between the mantra “A pairs with T, and G pairs with C” and the “intimidating” chemical diagrams.
Sergei Kuchin
doaj +1 more source
Pairing-based identification schemes
CoRR, 2005 We propose four different identification schemes that make use of bilinear pairings, and prove their security under certain computational assumptions. Each of the schemes is more efficient and/or more secure than any known pairing-based identification scheme.
openaire +3 more sources
BASE PAIRING IN 5-CHLOROURIDINE
Proceedings of the National Academy of Sciences, 1969 5-Chlorouridine has been found to crystallize from water with the molecules of the nucleoside arranged in a base-paired, parallel-stranded ribbon. This type of polymer structure has not been previously considered for nucleic acids. We have constructed a model of polyuridylic acid based upon the 5-chlorouridine crystal structure and wish to suggest it ...
C L, Coulter, S W, Hawkinson
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Stable stem enabled Shannon entropies distinguish non-coding RNAs from random backgrounds
BMC Bioinformatics, 2012 Background The computational identification of RNAs in genomic sequences requires the identification of signals of RNA sequences. Shannon base pairing entropy is an indicator for RNA secondary structure fold certainty in detection of structural, non ...
Wang Yingfeng +6 more
doaj +1 more source
Improved Cycle Sequencing of GC-Rich Templates by a Combination of Nucleotide Analogs
BioTechniques, 2000 A common problem in automated DNA sequencing when applying the Sanger chain termination method is ambiguous base calling caused by band compressions.
Michael Motz +2 more
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, 2014 Citation: 'base pairing' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.B00607 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source