Results 141 to 150 of about 3,508,819 (309)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Controls on spatio-temporal variability of exchangeable bases and base saturation in a dryland agricultural field [PDF]

open access: yes, 2017
Soil acidification threatens base cation status in agricultural soils in the semiarid Palouse River Basin of eastern Washington and northern Idaho, where over 65% of the region's surface 30 cm are acidified to below pH 6.
Jones, Kayla Beth
core   +1 more source

Variation in Culturable Rhizosphere Fungal Communities of Abies koreana in Mt. Jiri, Korea, in Relation to Topographic and Physicochemical Soil Properties

open access: yesMycobiology
This study was aimed at characterizing the culturable rhizosphere fungal community of Abies koreana on Mt. Jiri, Korea and to investigate the influence of topographic and physicochemical soil properties on them.
Jong Myong Park   +8 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Effects of Balancing Exchangeable Cations Ca, Mg, and K on the Growth of Tomato Seedlings (Solanum lycopersicum L.) Based on Increased Soil Cation Exchange Capacity

open access: yesAgronomy
(1) Background: Previous research has demonstrated that the cation exchange capacity (CEC) of soil and the balance of exchangeable cations Ca, Mg, and K are key factors affecting plant growth and development.
Mengyuan Yang   +8 more
doaj   +1 more source

Effect of soil base saturation and endomycorrhization on growth and nutrient status of sugar maple seedlings

open access: yes, 1996
Nutrient imbalances of declining sugar maple (Acer saccharum Marsh.) stands in southeastern Quebec have been associated partly with high soil exchangeable acidity and low base saturation on. A greenhouse experiment was set up to determine how growth and
Rock Ouimet   +2 more
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera   +20 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu   +10 more
wiley   +1 more source

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