Results 91 to 100 of about 6,391,316 (304)
Journal of Palaeogeography, 2014 According to the characteristics of sedimentary microfacies, unique vertical depositional sequences and well logging response, the authors propose that a shallow water delta was widely developed in the Neogene of the Laibei area, Bohai Bay Basin of ...
Jian-Ping Li +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action. [PDF]
Genes Genomics, 2022 Inokuchi H.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The RNA Ontology (RNAO): An ontology for integrating RNA sequence and structure data [PDF]
, 2009 Biomedical Ontologies are intended to integrate diverse biomedical data to enable intelligent data-mining and facilitate translation of basic research into useful clinical knowledge.
Eric Westhof +9 more
core
Predicting base editing outcomes using position-specific sequence determinants.
, 2022 CRISPR/Cas base editors promise nucleotide-level control over DNA sequences, but the determinants of their activity remain incompletely understood. We measured base editing frequencies in two human cell lines for two cytosine and two adenine base editors
Parts, L. +19 more
core +1 more source
Key controls of the gas and oil preferences of China's major coal-bearing sequences
Petroleum Exploration and Development, 2009 The key controls on the gas and oil preferences of coal-bearing strata are discussed from the relationship of material foundation between coal formation and hydrocarbon generation, the variation of the initial gas to oil ratio (GOR) of organic matter in ...
Zhong Ningning, Chen Gongyang
doaj +1 more source
Novel CRISPR-based sequence specific enrichment methods for target loci and single base mutations.
PLoS ONE, 2020 The programmable sequence specificity of CRISPR has found uses in gene editing and diagnostics. This manuscript describes an additional application of CRISPR through a family of novel DNA enrichment technologies.
Jennifer L Steele +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
BioTechniques, 2011 The analysis and profiling of short tandem repeat (STR) loci is routinely used in forensic genetics. Current methods to investigate STR loci, including PCR-based standard fragment analyses and capillary electrophoresis, only provide amplicon lengths that
Sarah L. Fordyce +9 more
doaj +1 more source